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Murine CD8 T‐cell functional avidity is stable in vivo but not in vitro: Independence from homologous prime/boost time interval and antigen density

It is known that for achieving high affinity antibody responses, vaccines must be optimized for antigen dose/density, and the prime/boost interval should be at least 4 weeks. Similar knowledge is lacking for generating high avidity T‐cell responses. The functional avidity (FA) of T cells, describing...

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Detalles Bibliográficos
Autores principales:	Gilfillan, Connie B., Wang, Chensu, Mohsen, Mona O., Rufer, Nathalie, Hebeisen, Michael, Allard, Mathilde, Verdeil, Grégory, Irvine, Darrell J., Bachmann, Martin F., Speiser, Daniel E.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2019
Materias:	Adaptive immunity
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187562/ https://www.ncbi.nlm.nih.gov/pubmed/31785153 http://dx.doi.org/10.1002/eji.201948355

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