Intracellular Pharmacodynamic Modeling Is Predictive of the Clinical Activity of Fluoroquinolones against Tuberculosis

Clinical studies of new antitubercular drugs are costly and time-consuming. Owing to the extensive tuberculosis (TB) treatment periods, the ability to identify drug candidates based on their predicted clinical efficacy is vital to accelerate the pipeline of new therapies. Recent failures of preclini...

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Detalles Bibliográficos
Autores principales: Donnellan, Samantha, Aljayyoussi, Ghaith, Moyo, Emmanuel, Ardrey, Alison, Martinez-Rodriguez, Carmen, Ward, Stephen A., Biagini, Giancarlo A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Clinical Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187570/
https://www.ncbi.nlm.nih.gov/pubmed/31611354
http://dx.doi.org/10.1128/AAC.00989-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187570/
https://www.ncbi.nlm.nih.gov/pubmed/31611354
http://dx.doi.org/10.1128/AAC.00989-19

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