Evaluation of Resistance Development to the Gwt1 Inhibitor Manogepix (APX001A) in Candida Species

Manogepix (MGX) targets the conserved fungal Gwt1 enzyme required for acylation of inositol early in the glycosylphosphatidylinositol biosynthesis pathway. The prodrug fosmanogepix is currently in clinical development for the treatment of invasive fungal infections. We determined that the median fre...

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Detalles Bibliográficos
Autores principales: Kapoor, Mili, Moloney, Molly, Soltow, Quinlyn A., Pillar, Chris M., Shaw, Karen Joy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Mechanisms of Resistance
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187586/
https://www.ncbi.nlm.nih.gov/pubmed/31611349
http://dx.doi.org/10.1128/AAC.01387-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187586/
https://www.ncbi.nlm.nih.gov/pubmed/31611349
http://dx.doi.org/10.1128/AAC.01387-19

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