Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials

The in vitro activities of five quinazolinone antibacterials, compounds Q1 to Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC(50)/MIC(90) values (in μg/ml) were as follows: Q1, 0.5/2; Q2, 1/4; Q3, 2/4; Q4, 0.06/0.25; and Q5, 0.125/0.5. Several strai...

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Autores principales: Ceballos, Sara, Kim, Choon, Qian, Yuanyuan, Mobashery, Shahriar, Chang, Mayland, Torres, Carmen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Susceptibility
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187613/
https://www.ncbi.nlm.nih.gov/pubmed/31611358
http://dx.doi.org/10.1128/AAC.01344-19
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author Ceballos, Sara
Kim, Choon
Qian, Yuanyuan
Mobashery, Shahriar
Chang, Mayland
Torres, Carmen
author_facet Ceballos, Sara
Kim, Choon
Qian, Yuanyuan
Mobashery, Shahriar
Chang, Mayland
Torres, Carmen
author_sort Ceballos, Sara
collection PubMed
description The in vitro activities of five quinazolinone antibacterials, compounds Q1 to Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC(50)/MIC(90) values (in μg/ml) were as follows: Q1, 0.5/2; Q2, 1/4; Q3, 2/4; Q4, 0.06/0.25; and Q5, 0.125/0.5. Several strains with high MIC values (from 8 to >32 μg/ml) for some of these compounds exhibited amino acid changes in the penicillin-binding proteins, which are targeted by these antibacterials.
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spelling pubmed-71876132020-04-28 Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials Ceballos, Sara Kim, Choon Qian, Yuanyuan Mobashery, Shahriar Chang, Mayland Torres, Carmen Antimicrob Agents Chemother Susceptibility The in vitro activities of five quinazolinone antibacterials, compounds Q1 to Q5, were tested against 210 strains of methicillin-resistant Staphylococcus aureus (MRSA). The MIC(50)/MIC(90) values (in μg/ml) were as follows: Q1, 0.5/2; Q2, 1/4; Q3, 2/4; Q4, 0.06/0.25; and Q5, 0.125/0.5. Several strains with high MIC values (from 8 to >32 μg/ml) for some of these compounds exhibited amino acid changes in the penicillin-binding proteins, which are targeted by these antibacterials. American Society for Microbiology 2019-12-20 /pmc/articles/PMC7187613/ /pubmed/31611358 http://dx.doi.org/10.1128/AAC.01344-19 Text en Copyright © 2019 Ceballos et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Susceptibility
Ceballos, Sara
Kim, Choon
Qian, Yuanyuan
Mobashery, Shahriar
Chang, Mayland
Torres, Carmen
Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials
title Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials
title_full Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials
title_fullStr Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials
title_full_unstemmed Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials
title_short Susceptibility of Methicillin-Resistant Staphylococcus aureus to Five Quinazolinone Antibacterials
title_sort susceptibility of methicillin-resistant staphylococcus aureus to five quinazolinone antibacterials
topic Susceptibility
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187613/
https://www.ncbi.nlm.nih.gov/pubmed/31611358
http://dx.doi.org/10.1128/AAC.01344-19
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