Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis

Galactomannan (GM) detection in biological samples has been shown to predict therapeutic response by azoles and polyenes. In a murine invasive pulmonary aspergillosis model, fosmanogepix or posaconazole treatment resulted in an ∼6- to 7-log reduction in conidial equivalents (CE)/g lung tissue after...

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Autores principales: Gebremariam, Teclegiorgis, Alkhazraji, Sondus, Gu, Yiyou, Singh, Shakti, Alqarihi, Abdullah, Shaw, Karen Joy, Ibrahim, Ashraf S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2019
Materias:
Experimental Therapeutics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187618/
https://www.ncbi.nlm.nih.gov/pubmed/31685475
http://dx.doi.org/10.1128/AAC.01966-19
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author Gebremariam, Teclegiorgis
Alkhazraji, Sondus
Gu, Yiyou
Singh, Shakti
Alqarihi, Abdullah
Shaw, Karen Joy
Ibrahim, Ashraf S.
author_facet Gebremariam, Teclegiorgis
Alkhazraji, Sondus
Gu, Yiyou
Singh, Shakti
Alqarihi, Abdullah
Shaw, Karen Joy
Ibrahim, Ashraf S.
author_sort Gebremariam, Teclegiorgis
collection PubMed
description Galactomannan (GM) detection in biological samples has been shown to predict therapeutic response by azoles and polyenes. In a murine invasive pulmonary aspergillosis model, fosmanogepix or posaconazole treatment resulted in an ∼6- to 7-log reduction in conidial equivalents (CE)/g lung tissue after 96 h versus placebo. Changes in GM levels in BAL fluid and serum mirrored reductions in lung CE, with significant decreases seen after 96 h or 72 h for fosmanogepix or posaconazole, respectively (P < 0.02).
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spelling pubmed-71876182020-04-28 Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis Gebremariam, Teclegiorgis Alkhazraji, Sondus Gu, Yiyou Singh, Shakti Alqarihi, Abdullah Shaw, Karen Joy Ibrahim, Ashraf S. Antimicrob Agents Chemother Experimental Therapeutics Galactomannan (GM) detection in biological samples has been shown to predict therapeutic response by azoles and polyenes. In a murine invasive pulmonary aspergillosis model, fosmanogepix or posaconazole treatment resulted in an ∼6- to 7-log reduction in conidial equivalents (CE)/g lung tissue after 96 h versus placebo. Changes in GM levels in BAL fluid and serum mirrored reductions in lung CE, with significant decreases seen after 96 h or 72 h for fosmanogepix or posaconazole, respectively (P < 0.02). American Society for Microbiology 2019-12-20 /pmc/articles/PMC7187618/ /pubmed/31685475 http://dx.doi.org/10.1128/AAC.01966-19 Text en Copyright © 2019 Gebremariam et al. https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution 4.0 International license (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Experimental Therapeutics
Gebremariam, Teclegiorgis
Alkhazraji, Sondus
Gu, Yiyou
Singh, Shakti
Alqarihi, Abdullah
Shaw, Karen Joy
Ibrahim, Ashraf S.
Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis
title Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis
title_full Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis
title_fullStr Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis
title_full_unstemmed Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis
title_short Galactomannan Is a Biomarker of Fosmanogepix (APX001) Efficacy in Treating Experimental Invasive Pulmonary Aspergillosis
title_sort galactomannan is a biomarker of fosmanogepix (apx001) efficacy in treating experimental invasive pulmonary aspergillosis
topic Experimental Therapeutics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187618/
https://www.ncbi.nlm.nih.gov/pubmed/31685475
http://dx.doi.org/10.1128/AAC.01966-19
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