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Multiple-Ascending-Dose Phase 1 Clinical Study of the Safety, Tolerability, and Pharmacokinetics of CRS3123, a Narrow-Spectrum Agent with Minimal Disruption of Normal Gut Microbiota

CRS3123 is a novel small molecule that potently inhibits methionyl-tRNA synthetase of Clostridioides difficile, inhibiting C. difficile toxin production and spore formation. CRS3123 has been evaluated in a multiple-ascending-dose placebo-controlled phase 1 trial. Thirty healthy subjects, ages 18 to...

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Detalles Bibliográficos
Autores principales:	Lomeli, Barbara K., Galbraith, Hal, Schettler, Jared, Saviolakis, George A., El-Amin, Wael, Osborn, Blaire, Ravel, Jacques, Hazleton, Keith, Lozupone, Catherine A., Evans, Ronald J., Bell, Stacie J., Ochsner, Urs A., Jarvis, Thale C., Baqar, Shahida, Janjic, Nebojsa
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2019
Materias:	Experimental Therapeutics
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187627/ https://www.ncbi.nlm.nih.gov/pubmed/31685472 http://dx.doi.org/10.1128/AAC.01395-19

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