Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer

Other iatrogenic immunodeficiency-associated lymphoproliferative disorders induced by immunosuppressive drugs, such as methotrexate (MTX-LPD), exhibit numerous pathological findings. We report the case of an 81-year-old Japanese woman diagnosed with MTX-LPD exhibiting two distinct pathological featu...

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Autores principales: Moriya, Keiichi, Kikuti, Yara Yukie, Carreras, Joaquim, Kondo, Yusuke, Shiraiwa, Sawako, Nakamura, Naoya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JSLRT 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187679/
https://www.ncbi.nlm.nih.gov/pubmed/32224560
http://dx.doi.org/10.3960/jslrt.19038
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author Moriya, Keiichi
Kikuti, Yara Yukie
Carreras, Joaquim
Kondo, Yusuke
Shiraiwa, Sawako
Nakamura, Naoya
author_facet Moriya, Keiichi
Kikuti, Yara Yukie
Carreras, Joaquim
Kondo, Yusuke
Shiraiwa, Sawako
Nakamura, Naoya
author_sort Moriya, Keiichi
collection PubMed
description Other iatrogenic immunodeficiency-associated lymphoproliferative disorders induced by immunosuppressive drugs, such as methotrexate (MTX-LPD), exhibit numerous pathological findings. We report the case of an 81-year-old Japanese woman diagnosed with MTX-LPD exhibiting two distinct pathological features from two different sites. Excisional biopsy of the left cervical lymph node revealed EBV-negative diffuse large B-cell lymphoma and biopsy of a pharyngeal ulcer revealed EBV-positive mucocutaneous ulcer. She was treated using an R-CHOP regimen and maintained complete remission for years. This case demonstrates the heterogeneous pathology of MTX-LPD and suggests the necessity of multiple biopsy.
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spelling pubmed-71876792020-04-29 Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer Moriya, Keiichi Kikuti, Yara Yukie Carreras, Joaquim Kondo, Yusuke Shiraiwa, Sawako Nakamura, Naoya J Clin Exp Hematop Case Report Other iatrogenic immunodeficiency-associated lymphoproliferative disorders induced by immunosuppressive drugs, such as methotrexate (MTX-LPD), exhibit numerous pathological findings. We report the case of an 81-year-old Japanese woman diagnosed with MTX-LPD exhibiting two distinct pathological features from two different sites. Excisional biopsy of the left cervical lymph node revealed EBV-negative diffuse large B-cell lymphoma and biopsy of a pharyngeal ulcer revealed EBV-positive mucocutaneous ulcer. She was treated using an R-CHOP regimen and maintained complete remission for years. This case demonstrates the heterogeneous pathology of MTX-LPD and suggests the necessity of multiple biopsy. JSLRT 2020-03-28 /pmc/articles/PMC7187679/ /pubmed/32224560 http://dx.doi.org/10.3960/jslrt.19038 Text en © 2020 by The Japanese Society for Lymphoreticular Tissue Research https://creativecommons.org/licenses/by-nc-sa/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution ShareAlike (CC BY-NC-SA) 4.0 License.
spellingShingle Case Report
Moriya, Keiichi
Kikuti, Yara Yukie
Carreras, Joaquim
Kondo, Yusuke
Shiraiwa, Sawako
Nakamura, Naoya
Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer
title Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer
title_full Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer
title_fullStr Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer
title_full_unstemmed Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer
title_short Methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of EBV-negative diffuse large B-cell lymphoma and EBV-positive mucocutaneous ulcer
title_sort methotrexate-associated lymphoproliferative disorder demonstrating composite lymphoma of ebv-negative diffuse large b-cell lymphoma and ebv-positive mucocutaneous ulcer
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187679/
https://www.ncbi.nlm.nih.gov/pubmed/32224560
http://dx.doi.org/10.3960/jslrt.19038
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