Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study

Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25‐hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25...

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Autores principales: Ali, Pauline, Labriffe, Matthieu, Navasiolava, Nastassia, Custaud, Marc‐Antoine, Dinomais, Mickaël, Annweiler, Cédric
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187697/
https://www.ncbi.nlm.nih.gov/pubmed/32150789
http://dx.doi.org/10.1002/acn3.50997
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author Ali, Pauline
Labriffe, Matthieu
Navasiolava, Nastassia
Custaud, Marc‐Antoine
Dinomais, Mickaël
Annweiler, Cédric
author_facet Ali, Pauline
Labriffe, Matthieu
Navasiolava, Nastassia
Custaud, Marc‐Antoine
Dinomais, Mickaël
Annweiler, Cédric
author_sort Ali, Pauline
collection PubMed
description Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25‐hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel‐based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE‐corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults.
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spelling pubmed-71876972020-04-29 Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study Ali, Pauline Labriffe, Matthieu Navasiolava, Nastassia Custaud, Marc‐Antoine Dinomais, Mickaël Annweiler, Cédric Ann Clin Transl Neurol Brief Communications Vitamin D is involved in brain health and function. Our objective was to determine whether lower 25‐hydroxyvitamin D (25OHD) concentration was associated with focal brain volume reduction in older adults. Serum 25OHD concentration was measured among 53 older adults (72 ± 5 years; 38% female; mean 25OHD = 67.3 ± 20.8 nmol/L). Gray matter volume (GMV) was automatically segmented using voxel‐based morphometry with CAT12 software. Covariables were age, gender, education, total intracranial volume, and season. Serum 25OHD was positively associated with GMV in left calcarine sulcus (P < 0.05, TFCE, FWE‐corrected). We found atrophy of the calcarine sulcus with lower 25OHD concentrations in older adults. John Wiley and Sons Inc. 2020-03-09 /pmc/articles/PMC7187697/ /pubmed/32150789 http://dx.doi.org/10.1002/acn3.50997 Text en © 2020 The Authors. Annals of Clinical and Translational Neurology published by Wiley Periodicals, Inc on behalf of American Neurological Association. This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Brief Communications
Ali, Pauline
Labriffe, Matthieu
Navasiolava, Nastassia
Custaud, Marc‐Antoine
Dinomais, Mickaël
Annweiler, Cédric
Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study
title Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study
title_full Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study
title_fullStr Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study
title_full_unstemmed Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study
title_short Vitamin D concentration and focal brain atrophy in older adults: a voxel‐based morphometric study
title_sort vitamin d concentration and focal brain atrophy in older adults: a voxel‐based morphometric study
topic Brief Communications
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187697/
https://www.ncbi.nlm.nih.gov/pubmed/32150789
http://dx.doi.org/10.1002/acn3.50997
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