Brain metabolic alterations herald falls in patients with Parkinson’s disease

Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious follow‐up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased...

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Detalles Bibliográficos
Autores principales: Isaias, Ioannis U., Brumberg, Joachim, Pozzi, Nicoló G., Palmisano, Chiara, Canessa, Andrea, Marotta, Giorgio, Volkmann, Jens, Pezzoli, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Brief Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187714/
https://www.ncbi.nlm.nih.gov/pubmed/32162447
http://dx.doi.org/10.1002/acn3.51013
Descripción
Sumario:Pathophysiological understanding of gait and balance disorders in Parkinson’s disease is insufficient and late recognition of fall risk limits efficacious follow‐up to prevent or delay falls. We show a distinctive reduction of glucose metabolism in the left posterior parietal cortex, with increased metabolic activity in the cerebellum, in parkinsonian patients 6–8 months before their first fall episode. Falls in Parkinson’s disease may arise from altered cortical processing of body spatial orientation, possibly predicted by abnormal cortical metabolism.

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