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Mutation of Isocitrate Dehydrogenase 1 in Cholangiocarcinoma Impairs Tumor Progression by Inhibiting Isocitrate Metabolism

Aim: Isocitrate dehydrogenase 1 (IDH1) is key enzyme involved in cellular metabolism and DNA repair. Mutations in IDH1 occur in up to 25% of cholangiocarcinomas. The present study aimed to explore the features of cellosaurus REB cells with mutant and wide-type IDH1. Methods: To compare the features...

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Detalles Bibliográficos
Autores principales:	Su, Li, Zhang, Xinglong, Zheng, Lei, Wang, Miaomiao, Zhu, Zhifa, Li, Ping
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Endocrinology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187788/ https://www.ncbi.nlm.nih.gov/pubmed/32373065 http://dx.doi.org/10.3389/fendo.2020.00189

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