COVID-19 vaccine design: the Janus face of immune enhancement

Previous work on severe acute respiratory syndrome coronavirus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as potential safety issues. We discuss the implications of these findings for COVID-19 vaccine development and our approach to optimizing for safe...

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Detalles Bibliográficos
Autores principales: Hotez, Peter J., Corry, David B., Bottazzi, Maria Elena
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187801/
https://www.ncbi.nlm.nih.gov/pubmed/32346094
http://dx.doi.org/10.1038/s41577-020-0323-4
Descripción
Sumario:Previous work on severe acute respiratory syndrome coronavirus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as potential safety issues. We discuss the implications of these findings for COVID-19 vaccine development and our approach to optimizing for safety and efficacy.

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