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COVID-19 vaccine design: the Janus face of immune enhancement
Previous work on severe acute respiratory syndrome coronavirus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as potential safety issues. We discuss the implications of these findings for COVID-19 vaccine development and our approach to optimizing for safe...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187801/ https://www.ncbi.nlm.nih.gov/pubmed/32346094 http://dx.doi.org/10.1038/s41577-020-0323-4 |
| _version_ | 1783527226068697088 |
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| author | Hotez, Peter J. Corry, David B. Bottazzi, Maria Elena |
| author_facet | Hotez, Peter J. Corry, David B. Bottazzi, Maria Elena |
| author_sort | Hotez, Peter J. |
| collection | PubMed |
| description | Previous work on severe acute respiratory syndrome coronavirus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as potential safety issues. We discuss the implications of these findings for COVID-19 vaccine development and our approach to optimizing for safety and efficacy. |
| format | Online Article Text |
| id | pubmed-7187801 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | Nature Publishing Group UK |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-71878012020-04-28 COVID-19 vaccine design: the Janus face of immune enhancement Hotez, Peter J. Corry, David B. Bottazzi, Maria Elena Nat Rev Immunol Comment Previous work on severe acute respiratory syndrome coronavirus (SARS-CoV) vaccines identified cellular immunopathology and antibody-dependent enhancement as potential safety issues. We discuss the implications of these findings for COVID-19 vaccine development and our approach to optimizing for safety and efficacy. Nature Publishing Group UK 2020-04-28 2020 /pmc/articles/PMC7187801/ /pubmed/32346094 http://dx.doi.org/10.1038/s41577-020-0323-4 Text en © Springer Nature Limited 2020 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
| spellingShingle | Comment Hotez, Peter J. Corry, David B. Bottazzi, Maria Elena COVID-19 vaccine design: the Janus face of immune enhancement |
| title | COVID-19 vaccine design: the Janus face of immune enhancement |
| title_full | COVID-19 vaccine design: the Janus face of immune enhancement |
| title_fullStr | COVID-19 vaccine design: the Janus face of immune enhancement |
| title_full_unstemmed | COVID-19 vaccine design: the Janus face of immune enhancement |
| title_short | COVID-19 vaccine design: the Janus face of immune enhancement |
| title_sort | covid-19 vaccine design: the janus face of immune enhancement |
| topic | Comment |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187801/ https://www.ncbi.nlm.nih.gov/pubmed/32346094 http://dx.doi.org/10.1038/s41577-020-0323-4 |
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