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Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019
Asthma is increasingly recognized as an underlying risk factor for severe respiratory disease in patients with coronavirus disease 2019 (COVID-19), particularly in the United States. Here, we report the postmortem lung findings from a 37-year-old man with asthma, who met the clinical criteria for se...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American College of Chest Physicians. Published by Elsevier Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187850/ https://www.ncbi.nlm.nih.gov/pubmed/32360729 http://dx.doi.org/10.1016/j.chest.2020.04.032 |
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author | Konopka, Kristine E. Wilson, Allecia Myers, Jeffrey L. |
author_facet | Konopka, Kristine E. Wilson, Allecia Myers, Jeffrey L. |
author_sort | Konopka, Kristine E. |
collection | PubMed |
description | Asthma is increasingly recognized as an underlying risk factor for severe respiratory disease in patients with coronavirus disease 2019 (COVID-19), particularly in the United States. Here, we report the postmortem lung findings from a 37-year-old man with asthma, who met the clinical criteria for severe acute respiratory distress syndrome and died of COVID-19 less than 2 weeks after presentation to the hospital. His lungs showed mucus plugging and other histologic changes attributable to asthma, as well as early diffuse alveolar damage and a fibrinous pneumonia. The presence of diffuse alveolar damage is similar to descriptions of autopsy lung findings from patients with severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, and the absence of a neutrophil-rich acute bronchopneumonia differs from the histologic changes typical of influenza. The relative contribution of mucus plugging to his hypoxemia is unknown. |
format | Online Article Text |
id | pubmed-7187850 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | American College of Chest Physicians. Published by Elsevier Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71878502020-04-28 Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019 Konopka, Kristine E. Wilson, Allecia Myers, Jeffrey L. Chest Novel Reports Asthma is increasingly recognized as an underlying risk factor for severe respiratory disease in patients with coronavirus disease 2019 (COVID-19), particularly in the United States. Here, we report the postmortem lung findings from a 37-year-old man with asthma, who met the clinical criteria for severe acute respiratory distress syndrome and died of COVID-19 less than 2 weeks after presentation to the hospital. His lungs showed mucus plugging and other histologic changes attributable to asthma, as well as early diffuse alveolar damage and a fibrinous pneumonia. The presence of diffuse alveolar damage is similar to descriptions of autopsy lung findings from patients with severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus, and the absence of a neutrophil-rich acute bronchopneumonia differs from the histologic changes typical of influenza. The relative contribution of mucus plugging to his hypoxemia is unknown. American College of Chest Physicians. Published by Elsevier Inc. 2020-09 2020-04-28 /pmc/articles/PMC7187850/ /pubmed/32360729 http://dx.doi.org/10.1016/j.chest.2020.04.032 Text en © 2020 American College of Chest Physicians. Published by Elsevier Inc. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Novel Reports Konopka, Kristine E. Wilson, Allecia Myers, Jeffrey L. Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019 |
title | Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019 |
title_full | Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019 |
title_fullStr | Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019 |
title_full_unstemmed | Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019 |
title_short | Postmortem Lung Findings in a Patient With Asthma and Coronavirus Disease 2019 |
title_sort | postmortem lung findings in a patient with asthma and coronavirus disease 2019 |
topic | Novel Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187850/ https://www.ncbi.nlm.nih.gov/pubmed/32360729 http://dx.doi.org/10.1016/j.chest.2020.04.032 |
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