A genome-wide enrichment screen identifies NUMA1-loss as a resistance mechanism against mitotic cell-death induced by BMI1 inhibition

BMI1 is a core protein of the polycomb repressive complex 1 (PRC1) that is overexpressed in several cancer types, making it a promising target for cancer therapies. However, the underlying mechanisms and interactions associated with BMI1-induced tumorigenesis are often context-dependent and complex....

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Detalles Bibliográficos
Autores principales: Gisler, Santiago, Maia, Ana Rita R., Chandrasekaran, Gayathri, Kopparam, Jawahar, van Lohuizen, Maarten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188281/
https://www.ncbi.nlm.nih.gov/pubmed/32343689
http://dx.doi.org/10.1371/journal.pone.0227592

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188281/
https://www.ncbi.nlm.nih.gov/pubmed/32343689
http://dx.doi.org/10.1371/journal.pone.0227592

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