Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera

Emergence of a new chronic myeloid neoplasm in the setting of a previous one, or their concomitant appearance seems to be a rare event, but plenty of cases have been reported. We describe the case of a patient with JAK2-V617F polycythemia vera, which looses JAK2 clone and develops overt BCR-ABL1 chr...

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Detalles Bibliográficos
Autores principales: Lorenzo, Mariana, Grille, Sofia, Stevenazzi, Mariana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elmer Press 2020
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188376/
https://www.ncbi.nlm.nih.gov/pubmed/32362982
http://dx.doi.org/10.14740/jh591
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author Lorenzo, Mariana
Grille, Sofia
Stevenazzi, Mariana
author_facet Lorenzo, Mariana
Grille, Sofia
Stevenazzi, Mariana
author_sort Lorenzo, Mariana
collection PubMed
description Emergence of a new chronic myeloid neoplasm in the setting of a previous one, or their concomitant appearance seems to be a rare event, but plenty of cases have been reported. We describe the case of a patient with JAK2-V617F polycythemia vera, which looses JAK2 clone and develops overt BCR-ABL1 chronic myeloid leukemia after 6 years. Once treatment with tyrosine kinase inhibitors controls BCR-ABL1 clone, JAK2 clone arises again. In this report, we review the literature and discuss the clonal relationship of this event in light of the new molecular data.
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spelling pubmed-71883762020-05-01 Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera Lorenzo, Mariana Grille, Sofia Stevenazzi, Mariana J Hematol Case Report Emergence of a new chronic myeloid neoplasm in the setting of a previous one, or their concomitant appearance seems to be a rare event, but plenty of cases have been reported. We describe the case of a patient with JAK2-V617F polycythemia vera, which looses JAK2 clone and develops overt BCR-ABL1 chronic myeloid leukemia after 6 years. Once treatment with tyrosine kinase inhibitors controls BCR-ABL1 clone, JAK2 clone arises again. In this report, we review the literature and discuss the clonal relationship of this event in light of the new molecular data. Elmer Press 2020-04 2020-04-23 /pmc/articles/PMC7188376/ /pubmed/32362982 http://dx.doi.org/10.14740/jh591 Text en Copyright 2020, Lorenzo et al. http://creativecommons.org/licenses/by-nc/4.0/ This article is distributed under the terms of the Creative Commons Attribution Non-Commercial 4.0 International License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Lorenzo, Mariana
Grille, Sofia
Stevenazzi, Mariana
Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera
title Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera
title_full Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera
title_fullStr Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera
title_full_unstemmed Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera
title_short Emergence of BCR-ABL1 Chronic Myeloid Leukemia in a JAK2-V617F Polycythemia Vera
title_sort emergence of bcr-abl1 chronic myeloid leukemia in a jak2-v617f polycythemia vera
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188376/
https://www.ncbi.nlm.nih.gov/pubmed/32362982
http://dx.doi.org/10.14740/jh591
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