Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats

The success of therapeutic antibodies is largely attributed for their exquisite specificity, homogeneity, and functionality. There is, however, a need to engineer antibodies to extend and enhance their potency. One parameter is functional affinity augmentation, since antibodies matured in vivo have...

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Detalles Bibliográficos
Autores principales: Miller, Ami, Carr, Stephen, Rabbitts, Terry, Ali, Hanif
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188389/
https://www.ncbi.nlm.nih.gov/pubmed/32316838
http://dx.doi.org/10.1080/19420862.2020.1752529

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188389/
https://www.ncbi.nlm.nih.gov/pubmed/32316838
http://dx.doi.org/10.1080/19420862.2020.1752529

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