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Multimeric antibodies with increased valency surpassing functional affinity and potency thresholds using novel formats
The success of therapeutic antibodies is largely attributed for their exquisite specificity, homogeneity, and functionality. There is, however, a need to engineer antibodies to extend and enhance their potency. One parameter is functional affinity augmentation, since antibodies matured in vivo have...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188389/ https://www.ncbi.nlm.nih.gov/pubmed/32316838 http://dx.doi.org/10.1080/19420862.2020.1752529 |