In vitro affinity optimization of an anti-BDNF monoclonal antibody translates to improved potency in targeting chronic pain states in vivo

The role of brain-derived neurotrophic factor (BDNF) signaling in chronic pain has been well documented. Given the important central role of BDNF in long term plasticity and memory, we sought to engineer a high affinity, peripherally-restricted monoclonal antibody against BDNF to modulate pain. BDNF...

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Detalles Bibliográficos
Autores principales: Stack, Edwina, McMurray, Sheridan, McMurray, Gordon, Wade, Jason, Clark, Melissa, Young, Gareth, Marquette, Kim, Jain, Sadhana, Kelleher, Kerry, Chen, Ting, Lin, Qingcong, Bloom, Laird, Lin, Laura, Finlay, William, Suzuki, Rie, Cunningham, Orla
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188400/
https://www.ncbi.nlm.nih.gov/pubmed/32329655
http://dx.doi.org/10.1080/19420862.2020.1755000

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