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Characterization of therapeutic proteins by cation exchange chromatography-mass spectrometry and top-down analysis

Recently, cation exchange chromatography (CEX) using aqueous volatile buffers was directly coupled with mass spectrometry (MS) and applied for intact analysis of therapeutic proteins and antibodies. In our study, chemical modifications responsible for charge variants were identified by CEX-UV-MS for...

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Detalles Bibliográficos
Autores principales:	Shi, Rachel Liuqing, Xiao, Gang, Dillon, Thomas M., Ricci, Margaret S., Bondarenko, Pavel V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2020
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188404/ https://www.ncbi.nlm.nih.gov/pubmed/32292112 http://dx.doi.org/10.1080/19420862.2020.1739825

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