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Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma

This study evaluated age-related trabecular meshwork (TM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance...

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Autores principales: Choi, Wungrak, Bae, Hyoung Won, Cho, Hyuna, Kim, Eun Woo, Kim, Chan Yun, Seong, Gong Je
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188680/
https://www.ncbi.nlm.nih.gov/pubmed/32346035
http://dx.doi.org/10.1038/s41598-020-64048-7
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author Choi, Wungrak
Bae, Hyoung Won
Cho, Hyuna
Kim, Eun Woo
Kim, Chan Yun
Seong, Gong Je
author_facet Choi, Wungrak
Bae, Hyoung Won
Cho, Hyuna
Kim, Eun Woo
Kim, Chan Yun
Seong, Gong Je
author_sort Choi, Wungrak
collection PubMed
description This study evaluated age-related trabecular meshwork (TM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance Hospital between January 2015 and June 2019. We randomly included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography (AS-OCT). The distance from the scleral spur to Schwalbe’s line in patients with normal open anterior chamber angle was measured using AS-OCT. Results were stratified based on patients’ age group—≤40, 41–50, 51–60, 61–70, 71–80, and 81–92 years. Thereafter, the results were compared among the age groups. The mean TM height of the patients was 770.929 ± 76.776 μm. TM height was 853.188 ± 94.117 μm in patients aged ≤40 years; it was 815.309 ± 75.723, 798.115 ± 66.040, 770.942 ± 52.774, 726.716 ± 63.979, and 715.968 ± 63.403 μm in patients aged 41–50, 51–60, 61–70, 71–80, and 81–92 years, respectively. The TM height tended to decrease with increasing age (P < 0.001). TM height was significantly shorter in older patients than in younger ones. Therefore, TM height may change with age and may contribute to increased glaucoma risk and prevalence.
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spelling pubmed-71886802020-05-04 Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma Choi, Wungrak Bae, Hyoung Won Cho, Hyuna Kim, Eun Woo Kim, Chan Yun Seong, Gong Je Sci Rep Article This study evaluated age-related trabecular meshwork (TM) height variations in the eyes of adults in different age groups. We hypothesised that a reduction in TM occurs with increasing age. This retrospective, cross-sectional, observational study was conducted at Yonsei University Gangnam Severance Hospital between January 2015 and June 2019. We randomly included 250 eyes of 125 patients who underwent anterior segment optical coherence tomography (AS-OCT). The distance from the scleral spur to Schwalbe’s line in patients with normal open anterior chamber angle was measured using AS-OCT. Results were stratified based on patients’ age group—≤40, 41–50, 51–60, 61–70, 71–80, and 81–92 years. Thereafter, the results were compared among the age groups. The mean TM height of the patients was 770.929 ± 76.776 μm. TM height was 853.188 ± 94.117 μm in patients aged ≤40 years; it was 815.309 ± 75.723, 798.115 ± 66.040, 770.942 ± 52.774, 726.716 ± 63.979, and 715.968 ± 63.403 μm in patients aged 41–50, 51–60, 61–70, 71–80, and 81–92 years, respectively. The TM height tended to decrease with increasing age (P < 0.001). TM height was significantly shorter in older patients than in younger ones. Therefore, TM height may change with age and may contribute to increased glaucoma risk and prevalence. Nature Publishing Group UK 2020-04-28 /pmc/articles/PMC7188680/ /pubmed/32346035 http://dx.doi.org/10.1038/s41598-020-64048-7 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Choi, Wungrak
Bae, Hyoung Won
Cho, Hyuna
Kim, Eun Woo
Kim, Chan Yun
Seong, Gong Je
Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma
title Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma
title_full Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma
title_fullStr Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma
title_full_unstemmed Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma
title_short Evaluation of the Relationship Between Age and Trabecular Meshwork Height to Predict the Risk of Glaucoma
title_sort evaluation of the relationship between age and trabecular meshwork height to predict the risk of glaucoma
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188680/
https://www.ncbi.nlm.nih.gov/pubmed/32346035
http://dx.doi.org/10.1038/s41598-020-64048-7
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