Cargando…
Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study
Musculoskeletal disorders are common among older people. Preventive strategies require understanding of age-related changes in strength, function and body composition, including how they interrelate. We have described, and examined associations between, 9-year changes in these parameters among 2917...
Autores principales: | , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer US
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188697/ https://www.ncbi.nlm.nih.gov/pubmed/32125471 http://dx.doi.org/10.1007/s00223-020-00679-2 |
_version_ | 1783527347418300416 |
---|---|
author | Westbury, Leo D. Syddall, Holly E. Fuggle, Nicholas R. Dennison, Elaine M. Cauley, Jane A. Shiroma, Eric J. Fielding, Roger A. Newman, Anne B. Cooper, Cyrus |
author_facet | Westbury, Leo D. Syddall, Holly E. Fuggle, Nicholas R. Dennison, Elaine M. Cauley, Jane A. Shiroma, Eric J. Fielding, Roger A. Newman, Anne B. Cooper, Cyrus |
author_sort | Westbury, Leo D. |
collection | PubMed |
description | Musculoskeletal disorders are common among older people. Preventive strategies require understanding of age-related changes in strength, function and body composition, including how they interrelate. We have described, and examined associations between, 9-year changes in these parameters among 2917 Health, Aging and Body Composition Study participants (aged 70–79 years). Appendicular lean mass (ALM), whole body fat mass and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. For each characteristic annualised percentage changes were calculated; measures of conditional change (independent of baseline) were derived and their interrelationships were examined using Pearson correlations; proportion of variance at 9-year follow-up explained by baseline level was estimated; and mean trajectories in relation to age were estimated using linear mixed models. Analyses were stratified by sex. Median [lower quartile, upper quartile] annual percentage declines were grip strength (1.5 [0.0, 2.9]), gait speed (2.0 [0.6, 3.7]), ALM (0.7 [0.1, 1.4]), fat mass (0.4 [− 1.1, 1.9]) and hip BMD (0.5 [0.0, 1.1]). Declines were linear for ALM and accelerated over time for other characteristics. Most conditional change measures were positively correlated, most strongly between ALM, fat mass and hip BMD (r > 0.28). Proportion of variation at follow-up explained by baseline was lower for grip strength and gait speed (39–52%) than other characteristics (69–86%). Strength and function declined more rapidly, and were less correlated between baseline and follow-up, than measures of body composition. Therefore, broader intervention strategies to prevent loss of strength and function in later life are required as those targeting body composition alone may be insufficient. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00223-020-00679-2) contains supplementary material, which is available to authorized users. |
format | Online Article Text |
id | pubmed-7188697 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer US |
record_format | MEDLINE/PubMed |
spelling | pubmed-71886972020-05-04 Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study Westbury, Leo D. Syddall, Holly E. Fuggle, Nicholas R. Dennison, Elaine M. Cauley, Jane A. Shiroma, Eric J. Fielding, Roger A. Newman, Anne B. Cooper, Cyrus Calcif Tissue Int Original Research Musculoskeletal disorders are common among older people. Preventive strategies require understanding of age-related changes in strength, function and body composition, including how they interrelate. We have described, and examined associations between, 9-year changes in these parameters among 2917 Health, Aging and Body Composition Study participants (aged 70–79 years). Appendicular lean mass (ALM), whole body fat mass and total hip BMD were ascertained using DXA; muscle strength by grip dynamometry; and muscle function by gait speed. For each characteristic annualised percentage changes were calculated; measures of conditional change (independent of baseline) were derived and their interrelationships were examined using Pearson correlations; proportion of variance at 9-year follow-up explained by baseline level was estimated; and mean trajectories in relation to age were estimated using linear mixed models. Analyses were stratified by sex. Median [lower quartile, upper quartile] annual percentage declines were grip strength (1.5 [0.0, 2.9]), gait speed (2.0 [0.6, 3.7]), ALM (0.7 [0.1, 1.4]), fat mass (0.4 [− 1.1, 1.9]) and hip BMD (0.5 [0.0, 1.1]). Declines were linear for ALM and accelerated over time for other characteristics. Most conditional change measures were positively correlated, most strongly between ALM, fat mass and hip BMD (r > 0.28). Proportion of variation at follow-up explained by baseline was lower for grip strength and gait speed (39–52%) than other characteristics (69–86%). Strength and function declined more rapidly, and were less correlated between baseline and follow-up, than measures of body composition. Therefore, broader intervention strategies to prevent loss of strength and function in later life are required as those targeting body composition alone may be insufficient. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00223-020-00679-2) contains supplementary material, which is available to authorized users. Springer US 2020-03-03 2020 /pmc/articles/PMC7188697/ /pubmed/32125471 http://dx.doi.org/10.1007/s00223-020-00679-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Original Research Westbury, Leo D. Syddall, Holly E. Fuggle, Nicholas R. Dennison, Elaine M. Cauley, Jane A. Shiroma, Eric J. Fielding, Roger A. Newman, Anne B. Cooper, Cyrus Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study |
title | Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study |
title_full | Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study |
title_fullStr | Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study |
title_full_unstemmed | Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study |
title_short | Long-term rates of change in musculoskeletal aging and body composition: findings from the Health, Aging and Body Composition Study |
title_sort | long-term rates of change in musculoskeletal aging and body composition: findings from the health, aging and body composition study |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188697/ https://www.ncbi.nlm.nih.gov/pubmed/32125471 http://dx.doi.org/10.1007/s00223-020-00679-2 |
work_keys_str_mv | AT westburyleod longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT syddallhollye longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT fugglenicholasr longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT dennisonelainem longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT cauleyjanea longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT shiromaericj longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT fieldingrogera longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT newmananneb longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy AT coopercyrus longtermratesofchangeinmusculoskeletalagingandbodycompositionfindingsfromthehealthagingandbodycompositionstudy |