Targeted Deep Sequencing Uncovers Cryptic KIT Mutations in KIT/PDGFRA/SDH/RAS-P Wild-Type GIST

Background: Gastrointestinal stromal tumors (GIST) are known to carry oncogenic KIT or PDGFRA mutations, or less commonly SDH or NF1 gene inactivation, with very rare cases harboring mutant BRAF or RAS alleles. Approximately 10% of GISTs are devoid of any of such mutations and are characterized by v...

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Detalles Bibliográficos
Autores principales: Astolfi, Annalisa, Indio, Valentina, Nannini, Margherita, Saponara, Maristella, Schipani, Angela, De Leo, Antonio, Altimari, Annalisa, Vincenzi, Bruno, Comandini, Danila, Grignani, Giovanni, Secchiero, Paola, Urbini, Milena, Pantaleo, Maria Abbondanza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188756/
https://www.ncbi.nlm.nih.gov/pubmed/32391261
http://dx.doi.org/10.3389/fonc.2020.00504

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