Chk1-mediated phosphorylation of Cdh1 promotes the SCF(βTRCP)-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression

APC/C(Cdh1) is a ubiquitin ligase with roles in numerous diverse processes, including control of cellular proliferation and multiple aspects of the DNA damage response. Precise regulation of APC/C(Cdh1) activity is central to efficient cell-cycle progression and cellular homeostasis. Here, we have i...

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Detalles Bibliográficos
Autores principales: Pal, Debjani, Torres, Adrian E., Stromberg, Benjamin R., Messina, Abbey L., Dickson, Andrew S., De, Kuntal, Willard, Belinda, Venere, Monica, Summers, Matthew K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188793/
https://www.ncbi.nlm.nih.gov/pubmed/32345958
http://dx.doi.org/10.1038/s41419-020-2493-1

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