Cargando…

Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns

Goal-directed behavior requires the representation of a task-set that defines the task-relevance of stimuli and guides stimulus-action mappings. Past experience provides one source of knowledge about likely task demands in the present, with learning enabling future predictions about anticipated dema...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Jiefeng, Wang, Shao-Fang, Guo, Wanjia, Fernandez, Corey, Wagner, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188806/
https://www.ncbi.nlm.nih.gov/pubmed/32345979
http://dx.doi.org/10.1038/s41467-020-15928-z
_version_ 1783527371891015680
author Jiang, Jiefeng
Wang, Shao-Fang
Guo, Wanjia
Fernandez, Corey
Wagner, Anthony D.
author_facet Jiang, Jiefeng
Wang, Shao-Fang
Guo, Wanjia
Fernandez, Corey
Wagner, Anthony D.
author_sort Jiang, Jiefeng
collection PubMed
description Goal-directed behavior requires the representation of a task-set that defines the task-relevance of stimuli and guides stimulus-action mappings. Past experience provides one source of knowledge about likely task demands in the present, with learning enabling future predictions about anticipated demands. We examine whether spatial contexts serve to cue retrieval of associated task demands (e.g., context A and B probabilistically cue retrieval of task demands X and Y, respectively), and the role of the hippocampus and dorsolateral prefrontal cortex (dlPFC) in mediating such retrieval. Using 3D virtual environments, we induce context-task demand probabilistic associations and find that learned associations affect goal-directed behavior. Concurrent fMRI data reveal that, upon entering a context, differences between hippocampal representations of contexts (i.e., neural pattern separability) predict proactive retrieval of the probabilistically dominant associated task demand, which is reinstated in dlPFC. These findings reveal how hippocampal-prefrontal interactions support memory-guided cognitive control and adaptive behavior.
format Online
Article
Text
id pubmed-7188806
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-71888062020-05-01 Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns Jiang, Jiefeng Wang, Shao-Fang Guo, Wanjia Fernandez, Corey Wagner, Anthony D. Nat Commun Article Goal-directed behavior requires the representation of a task-set that defines the task-relevance of stimuli and guides stimulus-action mappings. Past experience provides one source of knowledge about likely task demands in the present, with learning enabling future predictions about anticipated demands. We examine whether spatial contexts serve to cue retrieval of associated task demands (e.g., context A and B probabilistically cue retrieval of task demands X and Y, respectively), and the role of the hippocampus and dorsolateral prefrontal cortex (dlPFC) in mediating such retrieval. Using 3D virtual environments, we induce context-task demand probabilistic associations and find that learned associations affect goal-directed behavior. Concurrent fMRI data reveal that, upon entering a context, differences between hippocampal representations of contexts (i.e., neural pattern separability) predict proactive retrieval of the probabilistically dominant associated task demand, which is reinstated in dlPFC. These findings reveal how hippocampal-prefrontal interactions support memory-guided cognitive control and adaptive behavior. Nature Publishing Group UK 2020-04-28 /pmc/articles/PMC7188806/ /pubmed/32345979 http://dx.doi.org/10.1038/s41467-020-15928-z Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Jiang, Jiefeng
Wang, Shao-Fang
Guo, Wanjia
Fernandez, Corey
Wagner, Anthony D.
Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
title Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
title_full Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
title_fullStr Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
title_full_unstemmed Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
title_short Prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
title_sort prefrontal reinstatement of contextual task demand is predicted by separable hippocampal patterns
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188806/
https://www.ncbi.nlm.nih.gov/pubmed/32345979
http://dx.doi.org/10.1038/s41467-020-15928-z
work_keys_str_mv AT jiangjiefeng prefrontalreinstatementofcontextualtaskdemandispredictedbyseparablehippocampalpatterns
AT wangshaofang prefrontalreinstatementofcontextualtaskdemandispredictedbyseparablehippocampalpatterns
AT guowanjia prefrontalreinstatementofcontextualtaskdemandispredictedbyseparablehippocampalpatterns
AT fernandezcorey prefrontalreinstatementofcontextualtaskdemandispredictedbyseparablehippocampalpatterns
AT wagneranthonyd prefrontalreinstatementofcontextualtaskdemandispredictedbyseparablehippocampalpatterns