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Characterization of doxycycline-mediated inhibition of Marfan syndrome-associated aortic dilation by multiphoton microscopy
Marfan syndrome (MFS) is a connective tissue disorder that results in aortic root widening and aneurysm if unmanaged. We have previously reported doxycycline, a nonselective matrix metalloproteinases (MMPs) inhibitor, to attenuate aortic root widening and improve aortic contractility and elasticity...
Autores principales: | Tehrani, Arash Y., Cui, Jason Z., Bucky Jones, T., Hotova, Ester, Castro, Monica, Bernatchez, Pascal, van Breemen, Cornelis, Esfandiarei, Mitra |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188819/ https://www.ncbi.nlm.nih.gov/pubmed/32346027 http://dx.doi.org/10.1038/s41598-020-64071-8 |
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