The BRCA2-MEILB2-BRME1 complex governs meiotic recombination and impairs the mitotic BRCA2-RAD51 function in cancer cells

Breast cancer susceptibility gene II (BRCA2) is central in homologous recombination (HR). In meiosis, BRCA2 binds to MEILB2 to localize to DNA double-strand breaks (DSBs). Here, we identify BRCA2 and MEILB2-associating protein 1 (BRME1), which functions as a stabilizer of MEILB2 by binding to an α-h...

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Detalles Bibliográficos
Autores principales: Zhang, Jingjing, Gurusaran, Manickam, Fujiwara, Yasuhiro, Zhang, Kexin, Echbarthi, Meriem, Vorontsov, Egor, Guo, Rui, Pendlebury, Devon F., Alam, Intekhab, Livera, Gabriel, Emmanuelle, Martini, Wang, P. Jeremy, Nandakumar, Jayakrishnan, Davies, Owen R., Shibuya, Hiroki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188823/
https://www.ncbi.nlm.nih.gov/pubmed/32345962
http://dx.doi.org/10.1038/s41467-020-15954-x

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