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Comprehensive characterization of mainstream marijuana and tobacco smoke

Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke parti...

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Autores principales: Graves, Brian M., Johnson, Tyler J., Nishida, Robert T., Dias, Ryan P., Savareear, Benjamin, Harynuk, James J., Kazemimanesh, Mohsen, Olfert, Jason S., Boies, Adam M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188852/
https://www.ncbi.nlm.nih.gov/pubmed/32345986
http://dx.doi.org/10.1038/s41598-020-63120-6
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author Graves, Brian M.
Johnson, Tyler J.
Nishida, Robert T.
Dias, Ryan P.
Savareear, Benjamin
Harynuk, James J.
Kazemimanesh, Mohsen
Olfert, Jason S.
Boies, Adam M.
author_facet Graves, Brian M.
Johnson, Tyler J.
Nishida, Robert T.
Dias, Ryan P.
Savareear, Benjamin
Harynuk, James J.
Kazemimanesh, Mohsen
Olfert, Jason S.
Boies, Adam M.
author_sort Graves, Brian M.
collection PubMed
description Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke particles are quantitatively similar in volatility, shape, density and number concentration, albeit with differences in size, total mass and chemical composition. Particles from marijuana smoke are on average 29% larger in mobility diameter than particles from tobacco smoke and contain 3.4× more total mass. New measurements of semi-volatile fractions determine over 97% of the mass and volume of the particles from either smoke source are comprised of semi-volatile compounds. For tobacco and marijuana smoke, respectively, 4350 and 2575 different compounds are detected, of which, 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause negative health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. This study demonstrates striking similarities between marijuana and tobacco smoke in terms of their physical and chemical properties.
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spelling pubmed-71888522020-05-04 Comprehensive characterization of mainstream marijuana and tobacco smoke Graves, Brian M. Johnson, Tyler J. Nishida, Robert T. Dias, Ryan P. Savareear, Benjamin Harynuk, James J. Kazemimanesh, Mohsen Olfert, Jason S. Boies, Adam M. Sci Rep Article Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke particles are quantitatively similar in volatility, shape, density and number concentration, albeit with differences in size, total mass and chemical composition. Particles from marijuana smoke are on average 29% larger in mobility diameter than particles from tobacco smoke and contain 3.4× more total mass. New measurements of semi-volatile fractions determine over 97% of the mass and volume of the particles from either smoke source are comprised of semi-volatile compounds. For tobacco and marijuana smoke, respectively, 4350 and 2575 different compounds are detected, of which, 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause negative health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. This study demonstrates striking similarities between marijuana and tobacco smoke in terms of their physical and chemical properties. Nature Publishing Group UK 2020-04-28 /pmc/articles/PMC7188852/ /pubmed/32345986 http://dx.doi.org/10.1038/s41598-020-63120-6 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Graves, Brian M.
Johnson, Tyler J.
Nishida, Robert T.
Dias, Ryan P.
Savareear, Benjamin
Harynuk, James J.
Kazemimanesh, Mohsen
Olfert, Jason S.
Boies, Adam M.
Comprehensive characterization of mainstream marijuana and tobacco smoke
title Comprehensive characterization of mainstream marijuana and tobacco smoke
title_full Comprehensive characterization of mainstream marijuana and tobacco smoke
title_fullStr Comprehensive characterization of mainstream marijuana and tobacco smoke
title_full_unstemmed Comprehensive characterization of mainstream marijuana and tobacco smoke
title_short Comprehensive characterization of mainstream marijuana and tobacco smoke
title_sort comprehensive characterization of mainstream marijuana and tobacco smoke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188852/
https://www.ncbi.nlm.nih.gov/pubmed/32345986
http://dx.doi.org/10.1038/s41598-020-63120-6
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