Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice

This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of (18)F-fluorodeoxyglucose in atherosclerotic mice. T...

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Autores principales: Ståhle, Mia, Silvola, Johanna M.U., Hellberg, Sanna, de Vries, Margreet, Quax, Paul H.A., Kroon, Jeffrey, Rinne, Petteri, de Jong, Alwin, Liljenbäck, Heidi, Savisto, Nina, Wickman, Anna, Stroes, Erik S.G., Ylä-Herttuala, Seppo, Saukko, Pekka, Abrahamsson, Tommy, Pettersson, Knut, Knuuti, Juhani, Roivainen, Anne, Saraste, Antti
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
PRECLINICAL RESEARCH
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188869/
https://www.ncbi.nlm.nih.gov/pubmed/32368695
http://dx.doi.org/10.1016/j.jacbts.2020.01.008
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author Ståhle, Mia
Silvola, Johanna M.U.
Hellberg, Sanna
de Vries, Margreet
Quax, Paul H.A.
Kroon, Jeffrey
Rinne, Petteri
de Jong, Alwin
Liljenbäck, Heidi
Savisto, Nina
Wickman, Anna
Stroes, Erik S.G.
Ylä-Herttuala, Seppo
Saukko, Pekka
Abrahamsson, Tommy
Pettersson, Knut
Knuuti, Juhani
Roivainen, Anne
Saraste, Antti
author_facet Ståhle, Mia
Silvola, Johanna M.U.
Hellberg, Sanna
de Vries, Margreet
Quax, Paul H.A.
Kroon, Jeffrey
Rinne, Petteri
de Jong, Alwin
Liljenbäck, Heidi
Savisto, Nina
Wickman, Anna
Stroes, Erik S.G.
Ylä-Herttuala, Seppo
Saukko, Pekka
Abrahamsson, Tommy
Pettersson, Knut
Knuuti, Juhani
Roivainen, Anne
Saraste, Antti
author_sort Ståhle, Mia
collection PubMed
description This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of (18)F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies.
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spelling pubmed-71888692020-05-04 Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice Ståhle, Mia Silvola, Johanna M.U. Hellberg, Sanna de Vries, Margreet Quax, Paul H.A. Kroon, Jeffrey Rinne, Petteri de Jong, Alwin Liljenbäck, Heidi Savisto, Nina Wickman, Anna Stroes, Erik S.G. Ylä-Herttuala, Seppo Saukko, Pekka Abrahamsson, Tommy Pettersson, Knut Knuuti, Juhani Roivainen, Anne Saraste, Antti JACC Basic Transl Sci PRECLINICAL RESEARCH This study showed that treatment with a therapeutic monoclonal immunoglobulin-G1 antibody against phosphorylcholine on oxidized phospholipids preserves coronary flow reserve and attenuates atherosclerotic inflammation as determined by the uptake of (18)F-fluorodeoxyglucose in atherosclerotic mice. The noninvasive imaging techniques represent translational tools to assess the efficacy of phosphorylcholine-targeted therapy on coronary artery function and atherosclerosis in clinical studies. Elsevier 2020-03-25 /pmc/articles/PMC7188869/ /pubmed/32368695 http://dx.doi.org/10.1016/j.jacbts.2020.01.008 Text en © 2020 The Authors http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
spellingShingle PRECLINICAL RESEARCH
Ståhle, Mia
Silvola, Johanna M.U.
Hellberg, Sanna
de Vries, Margreet
Quax, Paul H.A.
Kroon, Jeffrey
Rinne, Petteri
de Jong, Alwin
Liljenbäck, Heidi
Savisto, Nina
Wickman, Anna
Stroes, Erik S.G.
Ylä-Herttuala, Seppo
Saukko, Pekka
Abrahamsson, Tommy
Pettersson, Knut
Knuuti, Juhani
Roivainen, Anne
Saraste, Antti
Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice
title Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice
title_full Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice
title_fullStr Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice
title_full_unstemmed Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice
title_short Therapeutic Antibody Against Phosphorylcholine Preserves Coronary Function and Attenuates Vascular (18)F-FDG Uptake in Atherosclerotic Mice
title_sort therapeutic antibody against phosphorylcholine preserves coronary function and attenuates vascular (18)f-fdg uptake in atherosclerotic mice
topic PRECLINICAL RESEARCH
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188869/
https://www.ncbi.nlm.nih.gov/pubmed/32368695
http://dx.doi.org/10.1016/j.jacbts.2020.01.008
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