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Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk
BACKGROUND: Whether depression before diagnosis of dyslipidemia is associated with higher cardiovascular disease (CVD) risk among newly diagnosed dyslipidemia patients is yet unclear. METHODS: The study population consisted of 72,235 newly diagnosed dyslipidemia patients during 2003 to 2012 from the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Diabetes Association
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188974/ https://www.ncbi.nlm.nih.gov/pubmed/31701694 http://dx.doi.org/10.4093/dmj.2019.0002 |
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author | Kim, Jihoon Andrew Choi, Seulggie Choi, Daein Park, Sang Min |
author_facet | Kim, Jihoon Andrew Choi, Seulggie Choi, Daein Park, Sang Min |
author_sort | Kim, Jihoon Andrew |
collection | PubMed |
description | BACKGROUND: Whether depression before diagnosis of dyslipidemia is associated with higher cardiovascular disease (CVD) risk among newly diagnosed dyslipidemia patients is yet unclear. METHODS: The study population consisted of 72,235 newly diagnosed dyslipidemia patients during 2003 to 2012 from the National Health Insurance Service–Health Screening Cohort of South Korea. Newly diagnosed dyslipidemia patients were then detected for pre-existing depression within 3 years before dyslipidemia diagnosis. Starting from 2 years after the diagnosis date, patients were followed up for CVD until 2015. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated by Cox proportional hazards regression. RESULTS: Compared to dyslipidemia patients without depression, those with depression had higher risk for CVD (aHR, 1.24; 95% CI, 1.09 to 1.41). Similarly, pre-existing depression was associated with increased risk for stroke (aHR, 1.27; 95% CI, 1.06 to 1.53). The risk for CVD among depressed dyslipidemia patients for high (aHR, 1.42; 95% CI, 1.06 to 1.90), medium (aHR, 1.17; 95% CI, 0.91 to 1.52), and low (aHR, 1.25; 95% CI, 1.05 to 1.50) statin compliance patients tended to be increased compared to patients without pre-existing dyslipidemia. The risk-elevating effect of depression on CVD tended to be preserved regardless of subgroups of smoking, alcohol consumption, physical activity, and body mass index. CONCLUSION: Dyslipidemia patients with pre-existing depression had increased risk for CVD. Future studies that determine CVD risk after management of depression among dyslipidemia patients are needed. |
format | Online Article Text |
id | pubmed-7188974 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Korean Diabetes Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-71889742020-05-06 Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk Kim, Jihoon Andrew Choi, Seulggie Choi, Daein Park, Sang Min Diabetes Metab J Original Article BACKGROUND: Whether depression before diagnosis of dyslipidemia is associated with higher cardiovascular disease (CVD) risk among newly diagnosed dyslipidemia patients is yet unclear. METHODS: The study population consisted of 72,235 newly diagnosed dyslipidemia patients during 2003 to 2012 from the National Health Insurance Service–Health Screening Cohort of South Korea. Newly diagnosed dyslipidemia patients were then detected for pre-existing depression within 3 years before dyslipidemia diagnosis. Starting from 2 years after the diagnosis date, patients were followed up for CVD until 2015. Adjusted hazard ratios (aHRs) and 95% confidence intervals (CIs) for CVD were calculated by Cox proportional hazards regression. RESULTS: Compared to dyslipidemia patients without depression, those with depression had higher risk for CVD (aHR, 1.24; 95% CI, 1.09 to 1.41). Similarly, pre-existing depression was associated with increased risk for stroke (aHR, 1.27; 95% CI, 1.06 to 1.53). The risk for CVD among depressed dyslipidemia patients for high (aHR, 1.42; 95% CI, 1.06 to 1.90), medium (aHR, 1.17; 95% CI, 0.91 to 1.52), and low (aHR, 1.25; 95% CI, 1.05 to 1.50) statin compliance patients tended to be increased compared to patients without pre-existing dyslipidemia. The risk-elevating effect of depression on CVD tended to be preserved regardless of subgroups of smoking, alcohol consumption, physical activity, and body mass index. CONCLUSION: Dyslipidemia patients with pre-existing depression had increased risk for CVD. Future studies that determine CVD risk after management of depression among dyslipidemia patients are needed. Korean Diabetes Association 2020-04 2019-11-01 /pmc/articles/PMC7188974/ /pubmed/31701694 http://dx.doi.org/10.4093/dmj.2019.0002 Text en Copyright © 2020 Korean Diabetes Association https://creativecommons.org/licenses/by-nc/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/ (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Kim, Jihoon Andrew Choi, Seulggie Choi, Daein Park, Sang Min Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk |
title | Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk |
title_full | Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk |
title_fullStr | Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk |
title_full_unstemmed | Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk |
title_short | Pre-existing Depression among Newly Diagnosed Dyslipidemia Patients and Cardiovascular Disease Risk |
title_sort | pre-existing depression among newly diagnosed dyslipidemia patients and cardiovascular disease risk |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7188974/ https://www.ncbi.nlm.nih.gov/pubmed/31701694 http://dx.doi.org/10.4093/dmj.2019.0002 |
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