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SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
BACKROUND AND AIMS: According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complicat...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Diabetes India. Published by Elsevier Ltd.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189186/ https://www.ncbi.nlm.nih.gov/pubmed/32387864 http://dx.doi.org/10.1016/j.dsx.2020.04.033 |
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author | Michalakis, Konstantinos Ilias, Ioannis |
author_facet | Michalakis, Konstantinos Ilias, Ioannis |
author_sort | Michalakis, Konstantinos |
collection | PubMed |
description | BACKROUND AND AIMS: According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection. METHODS: Pubmed search on obesity and SARS-CoV-2 infection. RESULTS: We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases. CONCLUSION: Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese. |
format | Online Article Text |
id | pubmed-7189186 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Diabetes India. Published by Elsevier Ltd. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71891862020-04-29 SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects Michalakis, Konstantinos Ilias, Ioannis Diabetes Metab Syndr Article BACKROUND AND AIMS: According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection. METHODS: Pubmed search on obesity and SARS-CoV-2 infection. RESULTS: We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases. CONCLUSION: Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese. Diabetes India. Published by Elsevier Ltd. 2020 2020-04-29 /pmc/articles/PMC7189186/ /pubmed/32387864 http://dx.doi.org/10.1016/j.dsx.2020.04.033 Text en © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Michalakis, Konstantinos Ilias, Ioannis SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects |
title | SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects |
title_full | SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects |
title_fullStr | SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects |
title_full_unstemmed | SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects |
title_short | SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects |
title_sort | sars-cov-2 infection and obesity: common inflammatory and metabolic aspects |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189186/ https://www.ncbi.nlm.nih.gov/pubmed/32387864 http://dx.doi.org/10.1016/j.dsx.2020.04.033 |
work_keys_str_mv | AT michalakiskonstantinos sarscov2infectionandobesitycommoninflammatoryandmetabolicaspects AT iliasioannis sarscov2infectionandobesitycommoninflammatoryandmetabolicaspects |