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SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects

BACKROUND AND AIMS: According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complicat...

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Autores principales: Michalakis, Konstantinos, Ilias, Ioannis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Diabetes India. Published by Elsevier Ltd. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189186/
https://www.ncbi.nlm.nih.gov/pubmed/32387864
http://dx.doi.org/10.1016/j.dsx.2020.04.033
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author Michalakis, Konstantinos
Ilias, Ioannis
author_facet Michalakis, Konstantinos
Ilias, Ioannis
author_sort Michalakis, Konstantinos
collection PubMed
description BACKROUND AND AIMS: According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection. METHODS: Pubmed search on obesity and SARS-CoV-2 infection. RESULTS: We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases. CONCLUSION: Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese.
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spelling pubmed-71891862020-04-29 SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects Michalakis, Konstantinos Ilias, Ioannis Diabetes Metab Syndr Article BACKROUND AND AIMS: According to the World Obesity Federation, “obesity-related conditions seem to worsen the effect of Covid-19 (SARS-CoV-2)”; additionally the Centres for Disease Control and Prevention reported that “people with heart disease and diabetes are at higher risk of SARS-CoV-2 complications and that severe obesity poses a higher risk for severe illness”. Recent reports have shown elevated levels of cytokines due to increased inflammation in patients with SARS-CoV-2 disease. On the other hand, obesity represents a state of low-grade inflammation, with various inflammatory products directly excreted by adipose tissue. In this concise report we aimed to assess common elements of obesity and SARS-CoV-2 infection. METHODS: Pubmed search on obesity and SARS-CoV-2 infection. RESULTS: We present “mechanistic” obesity-related problems that aggravate SARS-CoV-2 infection as well as tentative inflammatory/metabolic links between these diseases. CONCLUSION: Obesity and SARS-CoV-2 share common elements of the inflammatory process (and possibly also metabolic disturbances), exacerbating SARS-CoV-2 infection in the obese. Diabetes India. Published by Elsevier Ltd. 2020 2020-04-29 /pmc/articles/PMC7189186/ /pubmed/32387864 http://dx.doi.org/10.1016/j.dsx.2020.04.033 Text en © 2020 Diabetes India. Published by Elsevier Ltd. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Michalakis, Konstantinos
Ilias, Ioannis
SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
title SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
title_full SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
title_fullStr SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
title_full_unstemmed SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
title_short SARS-CoV-2 infection and obesity: Common inflammatory and metabolic aspects
title_sort sars-cov-2 infection and obesity: common inflammatory and metabolic aspects
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189186/
https://www.ncbi.nlm.nih.gov/pubmed/32387864
http://dx.doi.org/10.1016/j.dsx.2020.04.033
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