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Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19
There is an increasing number of confirmed cases and deaths caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributing to the Coronavirus disease 2019 (COVID-19) pandemic. At this point, the need for further disease characterization is critical. COVID-19 is well establis...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier B.V.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189193/ https://www.ncbi.nlm.nih.gov/pubmed/32388469 http://dx.doi.org/10.1016/j.jcv.2020.104386 |
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author | Patel, Kishan P. Patel, Puja A. Vunnam, Rama R. Hewlett, Alexander T. Jain, Rohit Jing, Ran Vunnam, Srinivas R. |
author_facet | Patel, Kishan P. Patel, Puja A. Vunnam, Rama R. Hewlett, Alexander T. Jain, Rohit Jing, Ran Vunnam, Srinivas R. |
author_sort | Patel, Kishan P. |
collection | PubMed |
description | There is an increasing number of confirmed cases and deaths caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributing to the Coronavirus disease 2019 (COVID-19) pandemic. At this point, the need for further disease characterization is critical. COVID-19 is well established as a respiratory tract pathogen; however, recent studies have shown an increasing number of patients reporting gastrointestinal manifestations such as diarrhea, nausea, vomiting, and abdominal pain. The time from onset of gastrointestinal symptoms to hospital presentation is often delayed compared to that of respiratory symptoms. It has been noted that SARS-CoV-2 RNA can be detected in fecal matter for an extended period of time, even after respiratory samples have tested negative and patients are asymptomatic. In this article, SARS-CoV-2 and its disease COVID-19 will be reviewed with consideration of the latest literature about gastrointestinal symptomatology, the mechanisms by which the virus may inflict damage, and the possibility of viral replication contributing to a fecal-oral route of transmission. |
format | Online Article Text |
id | pubmed-7189193 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Elsevier B.V. |
record_format | MEDLINE/PubMed |
spelling | pubmed-71891932020-04-29 Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 Patel, Kishan P. Patel, Puja A. Vunnam, Rama R. Hewlett, Alexander T. Jain, Rohit Jing, Ran Vunnam, Srinivas R. J Clin Virol Article There is an increasing number of confirmed cases and deaths caused by the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contributing to the Coronavirus disease 2019 (COVID-19) pandemic. At this point, the need for further disease characterization is critical. COVID-19 is well established as a respiratory tract pathogen; however, recent studies have shown an increasing number of patients reporting gastrointestinal manifestations such as diarrhea, nausea, vomiting, and abdominal pain. The time from onset of gastrointestinal symptoms to hospital presentation is often delayed compared to that of respiratory symptoms. It has been noted that SARS-CoV-2 RNA can be detected in fecal matter for an extended period of time, even after respiratory samples have tested negative and patients are asymptomatic. In this article, SARS-CoV-2 and its disease COVID-19 will be reviewed with consideration of the latest literature about gastrointestinal symptomatology, the mechanisms by which the virus may inflict damage, and the possibility of viral replication contributing to a fecal-oral route of transmission. Elsevier B.V. 2020-07 2020-04-29 /pmc/articles/PMC7189193/ /pubmed/32388469 http://dx.doi.org/10.1016/j.jcv.2020.104386 Text en © 2020 Elsevier B.V. All rights reserved. Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. |
spellingShingle | Article Patel, Kishan P. Patel, Puja A. Vunnam, Rama R. Hewlett, Alexander T. Jain, Rohit Jing, Ran Vunnam, Srinivas R. Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 |
title | Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 |
title_full | Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 |
title_fullStr | Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 |
title_full_unstemmed | Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 |
title_short | Gastrointestinal, hepatobiliary, and pancreatic manifestations of COVID-19 |
title_sort | gastrointestinal, hepatobiliary, and pancreatic manifestations of covid-19 |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189193/ https://www.ncbi.nlm.nih.gov/pubmed/32388469 http://dx.doi.org/10.1016/j.jcv.2020.104386 |
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