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Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors

Teenagers have a higher risk of invasive meningococcal disease (IMD) than the general population. This cross-sectional study aimed to characterise strains of Neisseria meningitidis circulating among Norwegian teenagers and to assess risk factors for meningococcal carriage. Oropharyngeal swabs were c...

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Autores principales: Watle, S. V., Caugant, D. A., Tunheim, G., Bekkevold, T., Laake, I., Brynildsrud, O. B., Næss, L. M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cambridge University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189347/
https://www.ncbi.nlm.nih.gov/pubmed/32228726
http://dx.doi.org/10.1017/S0950268820000734
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author Watle, S. V.
Caugant, D. A.
Tunheim, G.
Bekkevold, T.
Laake, I.
Brynildsrud, O. B.
Næss, L. M.
author_facet Watle, S. V.
Caugant, D. A.
Tunheim, G.
Bekkevold, T.
Laake, I.
Brynildsrud, O. B.
Næss, L. M.
author_sort Watle, S. V.
collection PubMed
description Teenagers have a higher risk of invasive meningococcal disease (IMD) than the general population. This cross-sectional study aimed to characterise strains of Neisseria meningitidis circulating among Norwegian teenagers and to assess risk factors for meningococcal carriage. Oropharyngeal swabs were collected from secondary-school students in southeastern Norway in 2018–2019. Meningococcal isolates were characterised using whole genome sequencing. Risk factors for meningococcal carriage were assessed from questionnaire data. Samples were obtained from 2296 12–24-year-olds (majority 13–19-year-olds). N. meningitidis was identified in 167 (7.3%) individuals. The highest carriage rate was found among 18-year-olds (16.4%). Most carriage isolates were capsule null (40.1%) or genogroup Y (33.5%). Clonal complexes cc23 (35.9%) and cc198 (32.3%) dominated and 38.9% of carriage strains were similar to invasive strains currently causing IMD in Norway. Use of Swedish snus (smokeless tobacco) (OR 1.56, 95% CI 1.07–2.27), kissing >two persons/month (OR 2.76, 95% CI 1.49–5.10) and partying >10 times/3months (OR 3.50, 95% CI 1.45–8.48) were associated with carriage, while age, cigarette smoking, sharing of drinking bottles and meningococcal vaccination were not. The high meningococcal carriage rate among 18-year-olds is probably due to risk-related behaviour. Use of Swedish snus is possibly a new risk factor for meningococcal carriage. Almost 40% of circulating carriage strains have invasive potential.
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spelling pubmed-71893472020-05-05 Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors Watle, S. V. Caugant, D. A. Tunheim, G. Bekkevold, T. Laake, I. Brynildsrud, O. B. Næss, L. M. Epidemiol Infect Original Paper Teenagers have a higher risk of invasive meningococcal disease (IMD) than the general population. This cross-sectional study aimed to characterise strains of Neisseria meningitidis circulating among Norwegian teenagers and to assess risk factors for meningococcal carriage. Oropharyngeal swabs were collected from secondary-school students in southeastern Norway in 2018–2019. Meningococcal isolates were characterised using whole genome sequencing. Risk factors for meningococcal carriage were assessed from questionnaire data. Samples were obtained from 2296 12–24-year-olds (majority 13–19-year-olds). N. meningitidis was identified in 167 (7.3%) individuals. The highest carriage rate was found among 18-year-olds (16.4%). Most carriage isolates were capsule null (40.1%) or genogroup Y (33.5%). Clonal complexes cc23 (35.9%) and cc198 (32.3%) dominated and 38.9% of carriage strains were similar to invasive strains currently causing IMD in Norway. Use of Swedish snus (smokeless tobacco) (OR 1.56, 95% CI 1.07–2.27), kissing >two persons/month (OR 2.76, 95% CI 1.49–5.10) and partying >10 times/3months (OR 3.50, 95% CI 1.45–8.48) were associated with carriage, while age, cigarette smoking, sharing of drinking bottles and meningococcal vaccination were not. The high meningococcal carriage rate among 18-year-olds is probably due to risk-related behaviour. Use of Swedish snus is possibly a new risk factor for meningococcal carriage. Almost 40% of circulating carriage strains have invasive potential. Cambridge University Press 2020-03-31 /pmc/articles/PMC7189347/ /pubmed/32228726 http://dx.doi.org/10.1017/S0950268820000734 Text en © The Author(s) 2020 http://creativecommons.org/licenses/by/4.0/ http://creativecommons.org/licenses/by/4.0/This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Paper
Watle, S. V.
Caugant, D. A.
Tunheim, G.
Bekkevold, T.
Laake, I.
Brynildsrud, O. B.
Næss, L. M.
Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors
title Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors
title_full Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors
title_fullStr Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors
title_full_unstemmed Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors
title_short Meningococcal carriage in Norwegian teenagers: strain characterisation and assessment of risk factors
title_sort meningococcal carriage in norwegian teenagers: strain characterisation and assessment of risk factors
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189347/
https://www.ncbi.nlm.nih.gov/pubmed/32228726
http://dx.doi.org/10.1017/S0950268820000734
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