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Chloroquine and bafilomycin A mimic lysosomal storage disorders and impair mTORC1 signalling

Autophagy is dependent upon lysosomes, which fuse with the autophagosome to complete the autophagic process and whose acidic interior permits the activity of their intraluminal degradative enzymes. Chloroquine (CQ) and bafilomycin A1 (BafA) each cause alkalinisation of the lumen and thus impair lyso...

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Detalles Bibliográficos
Autores principales:	Fedele, Anthony O., Proud, Christopher G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Cell Homeostasis & Autophagy
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189491/ https://www.ncbi.nlm.nih.gov/pubmed/32285908 http://dx.doi.org/10.1042/BSR20200905

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