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The cellular expression and proteolytic processing of the amyloid precursor protein is independent of TDP-43

Alzheimer’s disease (AD) is a neurodegenerative condition, of which one of the cardinal pathological hallmarks is the extracellular accumulation of amyloid β (Aβ) peptides. These peptides are generated via proteolysis of the amyloid precursor protein (APP), in a manner dependent on the β-secretase,...

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Detalles Bibliográficos
Autores principales:	Hicks, David A., Jones, Alys C., Pickering-Brown, Stuart M., Hooper, Nigel M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2020
Materias:	Molecular Bases of Health & Disease
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189496/ https://www.ncbi.nlm.nih.gov/pubmed/32301481 http://dx.doi.org/10.1042/BSR20200435

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