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Primary lymph node gastrinoma: a case report and review of the literature

BACKGROUND: Gastrinoma is a rare form of neuroendocrine neoplasm. The presence of a primary lymph node localization of gastrinoma is a much debated and controversial topic in the literature, as regards whether these cases represent metastatic disease from an as yet unidentified primary tumor, or the...

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Autores principales: Cavalcanti, Elisabetta, Stasi, Elisa, Coletta, Sergio, Lorusso, Dionigi, Rinaldi, Caterina Mammone, Armentano, Raffaele
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189517/
https://www.ncbi.nlm.nih.gov/pubmed/32345299
http://dx.doi.org/10.1186/s12957-020-01860-5
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author Cavalcanti, Elisabetta
Stasi, Elisa
Coletta, Sergio
Lorusso, Dionigi
Rinaldi, Caterina Mammone
Armentano, Raffaele
author_facet Cavalcanti, Elisabetta
Stasi, Elisa
Coletta, Sergio
Lorusso, Dionigi
Rinaldi, Caterina Mammone
Armentano, Raffaele
author_sort Cavalcanti, Elisabetta
collection PubMed
description BACKGROUND: Gastrinoma is a rare form of neuroendocrine neoplasm. The presence of a primary lymph node localization of gastrinoma is a much debated and controversial topic in the literature, as regards whether these cases represent metastatic disease from an as yet unidentified primary tumor, or the de novo occurrence of a gastrinoma in a lymph node. CASE PRESENTATION: We report the case of a 24-year-old male with intense epigastric pain treated at the beginning with high dose proton pump inhibitors. Further workup with CT and subsequent laparotomy revealed a single peripancreatic lymph node. Histological examination highlighted a well-differentiated neuroendocrine tumor. CONCLUSION: This case underlines that the primitive lymph node gastrinoma is a distinct nosological entity with a precise location in the context of rare neuroendocrine tumors that should be considered when specific symptoms are associated with the identification of isolated lymph nodes, after excluding any possible primitive locations of neoplastic localization.
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spelling pubmed-71895172020-05-04 Primary lymph node gastrinoma: a case report and review of the literature Cavalcanti, Elisabetta Stasi, Elisa Coletta, Sergio Lorusso, Dionigi Rinaldi, Caterina Mammone Armentano, Raffaele World J Surg Oncol Case Report BACKGROUND: Gastrinoma is a rare form of neuroendocrine neoplasm. The presence of a primary lymph node localization of gastrinoma is a much debated and controversial topic in the literature, as regards whether these cases represent metastatic disease from an as yet unidentified primary tumor, or the de novo occurrence of a gastrinoma in a lymph node. CASE PRESENTATION: We report the case of a 24-year-old male with intense epigastric pain treated at the beginning with high dose proton pump inhibitors. Further workup with CT and subsequent laparotomy revealed a single peripancreatic lymph node. Histological examination highlighted a well-differentiated neuroendocrine tumor. CONCLUSION: This case underlines that the primitive lymph node gastrinoma is a distinct nosological entity with a precise location in the context of rare neuroendocrine tumors that should be considered when specific symptoms are associated with the identification of isolated lymph nodes, after excluding any possible primitive locations of neoplastic localization. BioMed Central 2020-04-28 /pmc/articles/PMC7189517/ /pubmed/32345299 http://dx.doi.org/10.1186/s12957-020-01860-5 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Case Report
Cavalcanti, Elisabetta
Stasi, Elisa
Coletta, Sergio
Lorusso, Dionigi
Rinaldi, Caterina Mammone
Armentano, Raffaele
Primary lymph node gastrinoma: a case report and review of the literature
title Primary lymph node gastrinoma: a case report and review of the literature
title_full Primary lymph node gastrinoma: a case report and review of the literature
title_fullStr Primary lymph node gastrinoma: a case report and review of the literature
title_full_unstemmed Primary lymph node gastrinoma: a case report and review of the literature
title_short Primary lymph node gastrinoma: a case report and review of the literature
title_sort primary lymph node gastrinoma: a case report and review of the literature
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189517/
https://www.ncbi.nlm.nih.gov/pubmed/32345299
http://dx.doi.org/10.1186/s12957-020-01860-5
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