Strong associations and moderate predictive value of early symptoms for SARS-CoV-2 test positivity among healthcare workers, the Netherlands, March 2020

Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with...

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Detalles Bibliográficos
Autores principales: Tostmann, Alma, Bradley, John, Bousema, Teun, Yiek, Wing-Kee, Holwerda, Minke, Bleeker-Rovers, Chantal, ten Oever, Jaap, Meijer, Corianne, Rahamat-Langendoen, Janette, Hopman, Joost, van der Geest-Blankert, Nannet, Wertheim, Heiman
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2020
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189649/
https://www.ncbi.nlm.nih.gov/pubmed/32347200
http://dx.doi.org/10.2807/1560-7917.ES.2020.25.16.2000508
Descripción
Sumario:Healthcare workers (n = 803) with mild symptoms were tested for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (n = 90 positive) and asked to complete a symptom questionnaire. Anosmia, muscle ache, ocular pain, general malaise, headache, extreme tiredness and fever were associated with positivity. A predictive model based on these symptoms showed moderate discriminative value (sensitivity: 91.2%; specificity: 55.6%). While our models would not justify presumptive SARS-CoV-2 diagnosis without molecular confirmation, it can contribute to targeted screening strategies.

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