Enhanced accumulation of N-terminally truncated Aβ with and without pyroglutamate-11 modification in parvalbumin-expressing GABAergic neurons in idiopathic and dup15q11.2-q13 autism

Autism, the most frequent neurodevelopmental disorder of a very complex etiopathology, is associated with dysregulation of cellular homeostatic mechanisms, including processing of amyloid-β precursor protein (APP). Products of APP processing — N-terminally truncated amyloid-β peptide (N-tr-Aβ) speci...

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Detalles Bibliográficos
Autores principales: Frackowiak, Janusz, Mazur-Kolecka, Bozena, Mehta, Pankaj, Wegiel, Jerzy
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189730/
https://www.ncbi.nlm.nih.gov/pubmed/32345355
http://dx.doi.org/10.1186/s40478-020-00923-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189730/
https://www.ncbi.nlm.nih.gov/pubmed/32345355
http://dx.doi.org/10.1186/s40478-020-00923-8

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