Length-Dependent Structural Transformations of Huntingtin PolyQ Domain Upon Binding to 2D-Nanomaterials

There is a strong negative correlation between the polyglutamine (polyQ) domain length (Q-length) in the intrinsically disordered Huntingtin protein (Htt) exon-1 and the age of onset of Huntington's disease (HD). PolyQ of Q-length longer than 40 has the propensity of forming very compact aggreg...

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Detalles Bibliográficos
Autores principales: Feng, Mei, Bell, David R., Wang, Zhenhua, Zhang, Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189795/
https://www.ncbi.nlm.nih.gov/pubmed/32391325
http://dx.doi.org/10.3389/fchem.2020.00299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189795/
https://www.ncbi.nlm.nih.gov/pubmed/32391325
http://dx.doi.org/10.3389/fchem.2020.00299

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