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Impaired integrin α(5)/β(1)‐mediated hepatocyte growth factor release by stellate cells of the aged liver
Hepatic blood flow and sinusoidal endothelial fenestration decrease during aging. Consequently, fluid mechanical forces are reduced in the space of Disse where hepatic stellate cells (HSC) have their niche. We provide evidence that integrin α(5)/β(1) is an important mechanosensor in HSC involved in...
Autores principales: | Rohn, Friederike, Kordes, Claus, Buschmann, Tobias, Reichert, Doreen, Wammers, Marianne, Poschmann, Gereon, Stühler, Kai, Benk, Amelie S., Geiger, Fania, Spatz, Joachim P., Häussinger, Dieter |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189994/ https://www.ncbi.nlm.nih.gov/pubmed/32157808 http://dx.doi.org/10.1111/acel.13131 |
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