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Impaired integrin α(5)/β(1)‐mediated hepatocyte growth factor release by stellate cells of the aged liver

Hepatic blood flow and sinusoidal endothelial fenestration decrease during aging. Consequently, fluid mechanical forces are reduced in the space of Disse where hepatic stellate cells (HSC) have their niche. We provide evidence that integrin α(5)/β(1) is an important mechanosensor in HSC involved in...

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Detalles Bibliográficos
Autores principales:	Rohn, Friederike, Kordes, Claus, Buschmann, Tobias, Reichert, Doreen, Wammers, Marianne, Poschmann, Gereon, Stühler, Kai, Benk, Amelie S., Geiger, Fania, Spatz, Joachim P., Häussinger, Dieter
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2020
Materias:	Original Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7189994/ https://www.ncbi.nlm.nih.gov/pubmed/32157808 http://dx.doi.org/10.1111/acel.13131

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