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In vitro activity of AST-120 that suppresses indole signaling in Escherichia coli, which attenuates drug tolerance and virulence

AST-120 (Kremezin) is used to treat progressive chronic kidney disease (CKD) by adsorbing uremic toxin precursors produced by gut microbiota, such as indole and phenols. In this study, we propose that AST-120 reduces indole level, consequently suppresses indole effects on induction of drug tolerance...

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Detalles Bibliográficos
Autores principales:	Hirakawa, Hidetada, Uchida, Motoyuki, Kurabayashi, Kumiko, Nishijima, Fuyuhiko, Takita, Ayako, Tomita, Haruyoshi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190153/ https://www.ncbi.nlm.nih.gov/pubmed/32348373 http://dx.doi.org/10.1371/journal.pone.0232461

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