Loss of tetherin antagonism by Nef impairs SIV replication during acute infection of rhesus macaques

Most simian immunodeficiency viruses use Nef to counteract the tetherin proteins of their nonhuman primate hosts. Nef also downmodulates cell-surface CD4 and MHC class I (MHC I) molecules and enhances viral infectivity by counteracting SERINC5. We previously demonstrated that tetherin antagonism by...

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Detalles Bibliográficos
Autores principales: Tavakoli-Tameh, Aidin, Janaka, Sanath Kumar, Zarbock, Katie, O’Connor, Shelby, Crosno, Kristin, Capuano, Saverio, Uno, Hajime, Lifson, Jeffrey D., Evans, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190186/
https://www.ncbi.nlm.nih.gov/pubmed/32302364
http://dx.doi.org/10.1371/journal.ppat.1008487

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