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Research progress on myocardial regeneration: what is new?
The regeneration capacity of cardiomyocytes (CMs) is retained in neonatal mouse hearts but is limited in adult mouse hearts. Myocardial infarction (MI) in adult hearts usually leads to the loss of large amounts of cardiac tissue, and then accelerates the process of cardiac remodeling and heart failu...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190223/ https://www.ncbi.nlm.nih.gov/pubmed/32049749 http://dx.doi.org/10.1097/CM9.0000000000000693 |
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author | Du, Chong Fan, Yi Li, Ya-Fei Wei, Tian-Wen Wang, Lian-Sheng |
author_facet | Du, Chong Fan, Yi Li, Ya-Fei Wei, Tian-Wen Wang, Lian-Sheng |
author_sort | Du, Chong |
collection | PubMed |
description | The regeneration capacity of cardiomyocytes (CMs) is retained in neonatal mouse hearts but is limited in adult mouse hearts. Myocardial infarction (MI) in adult hearts usually leads to the loss of large amounts of cardiac tissue, and then accelerates the process of cardiac remodeling and heart failure. Therefore, it is necessary to explore the potential mechanisms of CM regeneration in the neonates and develop potential therapies aimed at promoting CM regeneration and cardiac repair in adults. Currently, studies indicate that a number of mechanisms are involved in neonatal endogenous myocardial regeneration, including cell cycle regulators, transcription factors, non-coding RNA, signaling pathways, acute inflammation, hypoxia, protein kinases, and others. Understanding the mechanisms of regeneration in neonatal CMs after MI provides theoretical support for the studies related to the promotion of heart repair after MI in adult mammals. However, several difficulties in the study of CM regeneration still need to be overcome. This article reviews the potential mechanisms of endogenous CM regeneration in neonatal mouse hearts and discusses possible therapeutic targets and future research directions. |
format | Online Article Text |
id | pubmed-7190223 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-71902232020-08-05 Research progress on myocardial regeneration: what is new? Du, Chong Fan, Yi Li, Ya-Fei Wei, Tian-Wen Wang, Lian-Sheng Chin Med J (Engl) Review Articles The regeneration capacity of cardiomyocytes (CMs) is retained in neonatal mouse hearts but is limited in adult mouse hearts. Myocardial infarction (MI) in adult hearts usually leads to the loss of large amounts of cardiac tissue, and then accelerates the process of cardiac remodeling and heart failure. Therefore, it is necessary to explore the potential mechanisms of CM regeneration in the neonates and develop potential therapies aimed at promoting CM regeneration and cardiac repair in adults. Currently, studies indicate that a number of mechanisms are involved in neonatal endogenous myocardial regeneration, including cell cycle regulators, transcription factors, non-coding RNA, signaling pathways, acute inflammation, hypoxia, protein kinases, and others. Understanding the mechanisms of regeneration in neonatal CMs after MI provides theoretical support for the studies related to the promotion of heart repair after MI in adult mammals. However, several difficulties in the study of CM regeneration still need to be overcome. This article reviews the potential mechanisms of endogenous CM regeneration in neonatal mouse hearts and discusses possible therapeutic targets and future research directions. Wolters Kluwer Health 2020-03-20 2020-03-20 /pmc/articles/PMC7190223/ /pubmed/32049749 http://dx.doi.org/10.1097/CM9.0000000000000693 Text en Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | Review Articles Du, Chong Fan, Yi Li, Ya-Fei Wei, Tian-Wen Wang, Lian-Sheng Research progress on myocardial regeneration: what is new? |
title | Research progress on myocardial regeneration: what is new? |
title_full | Research progress on myocardial regeneration: what is new? |
title_fullStr | Research progress on myocardial regeneration: what is new? |
title_full_unstemmed | Research progress on myocardial regeneration: what is new? |
title_short | Research progress on myocardial regeneration: what is new? |
title_sort | research progress on myocardial regeneration: what is new? |
topic | Review Articles |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190223/ https://www.ncbi.nlm.nih.gov/pubmed/32049749 http://dx.doi.org/10.1097/CM9.0000000000000693 |
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