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Research progress on myocardial regeneration: what is new?

The regeneration capacity of cardiomyocytes (CMs) is retained in neonatal mouse hearts but is limited in adult mouse hearts. Myocardial infarction (MI) in adult hearts usually leads to the loss of large amounts of cardiac tissue, and then accelerates the process of cardiac remodeling and heart failu...

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Autores principales: Du, Chong, Fan, Yi, Li, Ya-Fei, Wei, Tian-Wen, Wang, Lian-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190223/
https://www.ncbi.nlm.nih.gov/pubmed/32049749
http://dx.doi.org/10.1097/CM9.0000000000000693
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author Du, Chong
Fan, Yi
Li, Ya-Fei
Wei, Tian-Wen
Wang, Lian-Sheng
author_facet Du, Chong
Fan, Yi
Li, Ya-Fei
Wei, Tian-Wen
Wang, Lian-Sheng
author_sort Du, Chong
collection PubMed
description The regeneration capacity of cardiomyocytes (CMs) is retained in neonatal mouse hearts but is limited in adult mouse hearts. Myocardial infarction (MI) in adult hearts usually leads to the loss of large amounts of cardiac tissue, and then accelerates the process of cardiac remodeling and heart failure. Therefore, it is necessary to explore the potential mechanisms of CM regeneration in the neonates and develop potential therapies aimed at promoting CM regeneration and cardiac repair in adults. Currently, studies indicate that a number of mechanisms are involved in neonatal endogenous myocardial regeneration, including cell cycle regulators, transcription factors, non-coding RNA, signaling pathways, acute inflammation, hypoxia, protein kinases, and others. Understanding the mechanisms of regeneration in neonatal CMs after MI provides theoretical support for the studies related to the promotion of heart repair after MI in adult mammals. However, several difficulties in the study of CM regeneration still need to be overcome. This article reviews the potential mechanisms of endogenous CM regeneration in neonatal mouse hearts and discusses possible therapeutic targets and future research directions.
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spelling pubmed-71902232020-08-05 Research progress on myocardial regeneration: what is new? Du, Chong Fan, Yi Li, Ya-Fei Wei, Tian-Wen Wang, Lian-Sheng Chin Med J (Engl) Review Articles The regeneration capacity of cardiomyocytes (CMs) is retained in neonatal mouse hearts but is limited in adult mouse hearts. Myocardial infarction (MI) in adult hearts usually leads to the loss of large amounts of cardiac tissue, and then accelerates the process of cardiac remodeling and heart failure. Therefore, it is necessary to explore the potential mechanisms of CM regeneration in the neonates and develop potential therapies aimed at promoting CM regeneration and cardiac repair in adults. Currently, studies indicate that a number of mechanisms are involved in neonatal endogenous myocardial regeneration, including cell cycle regulators, transcription factors, non-coding RNA, signaling pathways, acute inflammation, hypoxia, protein kinases, and others. Understanding the mechanisms of regeneration in neonatal CMs after MI provides theoretical support for the studies related to the promotion of heart repair after MI in adult mammals. However, several difficulties in the study of CM regeneration still need to be overcome. This article reviews the potential mechanisms of endogenous CM regeneration in neonatal mouse hearts and discusses possible therapeutic targets and future research directions. Wolters Kluwer Health 2020-03-20 2020-03-20 /pmc/articles/PMC7190223/ /pubmed/32049749 http://dx.doi.org/10.1097/CM9.0000000000000693 Text en Copyright © 2020 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle Review Articles
Du, Chong
Fan, Yi
Li, Ya-Fei
Wei, Tian-Wen
Wang, Lian-Sheng
Research progress on myocardial regeneration: what is new?
title Research progress on myocardial regeneration: what is new?
title_full Research progress on myocardial regeneration: what is new?
title_fullStr Research progress on myocardial regeneration: what is new?
title_full_unstemmed Research progress on myocardial regeneration: what is new?
title_short Research progress on myocardial regeneration: what is new?
title_sort research progress on myocardial regeneration: what is new?
topic Review Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190223/
https://www.ncbi.nlm.nih.gov/pubmed/32049749
http://dx.doi.org/10.1097/CM9.0000000000000693
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