Intracellular delivery of Parkin rescues neurons from accumulation of damaged mitochondria and pathological α-synuclein

Parkinson’s disease (PD) is a progressive neurodegenerative disorder characterized by mitochondrial dysfunction, Lewy body formation, and loss of dopaminergic neurons. Parkin, an E3 ubiquitin ligase, is thought to inhibit PD progression by removing damaged mitochondria and suppressing the accumulati...

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Detalles Bibliográficos
Autores principales: Chung, Eunna, Choi, Youngsil, Park, Jiae, Nah, Wonheum, Park, Jaehyung, Jung, Yukdong, Lee, Joonno, Lee, Hyunji, Park, Soyoung, Hwang, Sunyoung, Kim, Seongcheol, Lee, Jongseok, Min, Dongjae, Jo, Junghwan, Kang, Shinyoung, Jung, Minyong, Lee, Phil Hyu, Ruley, H. Earl, Jo, Daewoong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190327/
https://www.ncbi.nlm.nih.gov/pubmed/32494688
http://dx.doi.org/10.1126/sciadv.aba1193

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190327/
https://www.ncbi.nlm.nih.gov/pubmed/32494688
http://dx.doi.org/10.1126/sciadv.aba1193

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