Cargando…
Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer
Radiation is a significant treatment for patients with head and neck cancer. Despite advances to improve treatment, many tumors acquire radiation resistance resulting in poor survival. Radiation kills cancer cells by inducing DNA double-strand breaks. Therefore, radiation resistance is enhanced by e...
Autores principales: | , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190570/ https://www.ncbi.nlm.nih.gov/pubmed/32157215 http://dx.doi.org/10.1038/s41388-020-1250-3 |
_version_ | 1783527708491251712 |
---|---|
author | Hutchinson, Marsha-Kay N. D. Mierzwa, Michelle D’Silva, Nisha J. |
author_facet | Hutchinson, Marsha-Kay N. D. Mierzwa, Michelle D’Silva, Nisha J. |
author_sort | Hutchinson, Marsha-Kay N. D. |
collection | PubMed |
description | Radiation is a significant treatment for patients with head and neck cancer. Despite advances to improve treatment, many tumors acquire radiation resistance resulting in poor survival. Radiation kills cancer cells by inducing DNA double-strand breaks. Therefore, radiation resistance is enhanced by efficient repair of damaged DNA. Head and neck cancers overexpress EGFR and have a high frequency of p53 mutations, both of which enhance DNA repair. This review discusses the clinical criteria for radiation resistance in patients with head and neck cancer and summarizes how cancer cells evade radiation-mediated apoptosis by p53- and epidermal growth factor receptor (EGFR)-mediated DNA repair. In addition, we explore the role of cancer stem cells in promoting radiation resistance, and how the abscopal effect provides rationale for combination strategies with immunotherapy. |
format | Online Article Text |
id | pubmed-7190570 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Nature Publishing Group UK |
record_format | MEDLINE/PubMed |
spelling | pubmed-71905702020-05-04 Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer Hutchinson, Marsha-Kay N. D. Mierzwa, Michelle D’Silva, Nisha J. Oncogene Review Article Radiation is a significant treatment for patients with head and neck cancer. Despite advances to improve treatment, many tumors acquire radiation resistance resulting in poor survival. Radiation kills cancer cells by inducing DNA double-strand breaks. Therefore, radiation resistance is enhanced by efficient repair of damaged DNA. Head and neck cancers overexpress EGFR and have a high frequency of p53 mutations, both of which enhance DNA repair. This review discusses the clinical criteria for radiation resistance in patients with head and neck cancer and summarizes how cancer cells evade radiation-mediated apoptosis by p53- and epidermal growth factor receptor (EGFR)-mediated DNA repair. In addition, we explore the role of cancer stem cells in promoting radiation resistance, and how the abscopal effect provides rationale for combination strategies with immunotherapy. Nature Publishing Group UK 2020-03-10 2020 /pmc/articles/PMC7190570/ /pubmed/32157215 http://dx.doi.org/10.1038/s41388-020-1250-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Article Hutchinson, Marsha-Kay N. D. Mierzwa, Michelle D’Silva, Nisha J. Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer |
title | Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer |
title_full | Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer |
title_fullStr | Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer |
title_full_unstemmed | Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer |
title_short | Radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer |
title_sort | radiation resistance in head and neck squamous cell carcinoma: dire need for an appropriate sensitizer |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190570/ https://www.ncbi.nlm.nih.gov/pubmed/32157215 http://dx.doi.org/10.1038/s41388-020-1250-3 |
work_keys_str_mv | AT hutchinsonmarshakaynd radiationresistanceinheadandnecksquamouscellcarcinomadireneedforanappropriatesensitizer AT mierzwamichelle radiationresistanceinheadandnecksquamouscellcarcinomadireneedforanappropriatesensitizer AT dsilvanishaj radiationresistanceinheadandnecksquamouscellcarcinomadireneedforanappropriatesensitizer |