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Partial impairment of insulin receptor expression mimics fasting to prevent diet-induced fatty liver disease
Excessive insulin signaling through the insulin receptor (IR) may play a role in the pathogenesis of diet-induced metabolic disease, including obesity and type 2 diabetes. Here we investigate whether heterozygous impairment of insulin receptor (IR) expression limited to peripheral, i.e. non-CNS, tis...
Autores principales: | Merry, Troy L., Hedges, Chris P., Masson, Stewart W., Laube, Beate, Pöhlmann, Doris, Wueest, Stephan, Walsh, Michael E., Arnold, Myrtha, Langhans, Wolfgang, Konrad, Daniel, Zarse, Kim, Ristow, Michael |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190665/ https://www.ncbi.nlm.nih.gov/pubmed/32350271 http://dx.doi.org/10.1038/s41467-020-15623-z |
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