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Intron retention is a hallmark and spliceosome represents a therapeutic vulnerability in aggressive prostate cancer

The role of dysregulation of mRNA alternative splicing (AS) in the development and progression of solid tumors remains to be defined. Here we describe the first comprehensive AS landscape in the spectrum of human prostate cancer (PCa) evolution. We find that the severity of splicing dysregulation co...

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Detalles Bibliográficos
Autores principales:	Zhang, Dingxiao, Hu, Qiang, Liu, Xiaozhuo, Ji, Yibing, Chao, Hsueh-Ping, Liu, Yan, Tracz, Amanda, Kirk, Jason, Buonamici, Silvia, Zhu, Ping, Wang, Jianmin, Liu, Song, Tang, Dean G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190674/ https://www.ncbi.nlm.nih.gov/pubmed/32350277 http://dx.doi.org/10.1038/s41467-020-15815-7

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