Cargando…

The Effect of Force-Field Parameters on Cytochrome P450-Membrane Interactions: Structure and Dynamics

The simulation of membrane proteins requires compatible protein and lipid force fields that reproduce the properties of both the protein and the lipid bilayer. Cytochrome P450 enzymes are bitopic membrane proteins with a transmembrane helical anchor and a large cytosolic globular domain that dips in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Mustafa, Ghulam, Nandekar, Prajwal P., Mukherjee, Goutam, Bruce, Neil J., Wade, Rebecca C.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190701/ https://www.ncbi.nlm.nih.gov/pubmed/32350331 http://dx.doi.org/10.1038/s41598-020-64129-7

Ejemplares similares

An electron transfer competent structural ensemble of membrane-bound cytochrome P450 1A1 and cytochrome P450 oxidoreductase
por: Mukherjee, Goutam, et al.
Publicado: (2021)

Differing Membrane Interactions of Two Highly Similar Drug-Metabolizing Cytochrome P450 Isoforms: CYP 2C9 and CYP 2C19
por: Mustafa, Ghulam, et al.
Publicado: (2019)

Influence of Transmembrane Helix Mutations on Cytochrome P450-Membrane Interactions and Function
por: Mustafa, Ghulam, et al.
Publicado: (2019)

Structure and Dynamics of the Membrane-Bound Cytochrome P450 2C9
por: Cojocaru, Vlad, et al.
Publicado: (2011)

Probing the Role of the Hinge Segment of Cytochrome P450 Oxidoreductase in the Interaction with Cytochrome P450
por: Campelo, Diana, et al.
Publicado: (2018)

Dynamic Interaction Between Membrane-Bound Full-Length Cytochrome P450 and Cytochrome b(5) Observed by Solid-State NMR Spectroscopy
por: Yamamoto, Kazutoshi, et al.
Publicado: (2013)

Computational identification of natural product inhibitors against EGFR double mutant (T790M/L858R) by integrating ADMET, machine learning, molecular docking and a dynamics approach
por: Agarwal, Subhash M., et al.
Publicado: (2022)

Role of cytochrome P450 in drug interactions
por: Bibi, Zakia
Publicado: (2008)

Inter-subunit interactions drive divergent dynamics in mammalian and Plasmodium actin filaments
por: Douglas, Ross G., et al.
Publicado: (2018)

The Cytochrome P450 Homepage
por: Nelson, David R
Publicado: (2009)

Interaction potential of Trigonella foenum graceum through cytochrome P450 mediated inhibition
por: Ahmmed, Sk Milan, et al.
Publicado: (2015)

Signals for the incorporation and orientation of cytochrome P450 in the endoplasmic reticulum membrane
Publicado: (1988)

The FMN “140s Loop” of Cytochrome P450 Reductase Controls Electron Transfer to Cytochrome P450
por: Rwere, Freeborn, et al.
Publicado: (2021)

Retraction: Role of cytochrome P450 in drug interactions
por: Bibi, Zakia
Publicado: (2014)

Conformational Landscape of Cytochrome P450 Reductase Interactions
por: Sellner, Manuel, et al.
Publicado: (2021)

Effect of Salts on the Conformational Dynamics of the Cytochrome P450 OleP
por: De Sciscio, Maria Laura, et al.
Publicado: (2023)

The catalytic function of cytochrome P450 is entwined with its membrane-bound nature
por: Barnaba, Carlo, et al.
Publicado: (2017)

Fungal cytochrome P450 database
por: Park, Jongsun, et al.
Publicado: (2008)

Cytochrome P450 humanised mice
por: Gonzalez, Frank J
Publicado: (2004)

Intronic polymorphisms of cytochromes P450
por: Ingelman-Sundberg, Magnus, et al.
Publicado: (2010)

The Role of Cytochromes P450 in Infection
por: Stavropoulou, Elisavet, et al.
Publicado: (2018)

Cytochromes P450, Oxygen, and Evolution
por: Lewis, David F.V., et al.
Publicado: (2001)

Correlation of Cytochrome P450 Oxidoreductase Expression with the Expression of 10 Isoforms of Cytochrome P450 in Human Liver
por: Zhang, Hai-Feng, et al.
Publicado: (2016)

1-Aminobenzotriazole: A Mechanism-Based Cytochrome P450 Inhibitor and Probe of Cytochrome P450 Biology
por: de Montellano, Paul R Ortiz
Publicado: (2018)

Allosteric modulation of cytochrome P450 enzymes by the NADPH cytochrome P450 reductase FMN-containing domain
por: Burris-Hiday, Sarah D., et al.
Publicado: (2023)

Molecular evolutionary dynamics of cytochrome P450 monooxygenases across kingdoms: Special focus on mycobacterial P450s
por: Parvez, Mohammad, et al.
Publicado: (2016)

Membrane Associated Progesterone Receptors: Promiscuous Proteins with Pleiotropic Functions – Focus on Interactions with Cytochromes P450
por: Ryu, Chang S., et al.
Publicado: (2017)

Cytochrome P450-Mediated Phytoremediation using Transgenic Plants: A Need for Engineered Cytochrome P450 Enzymes
por: Kumar, Santosh, et al.
Publicado: (2012)

The cytochrome P450 isoenzyme and some new opportunities for the prediction of negative drug interaction in vivo
por: Sychev, Dmitrij A, et al.
Publicado: (2018)

Pharmacokinetic Interactions of Herbs with Cytochrome P450 and P-Glycoprotein
por: Cho, Hyun-Jong, et al.
Publicado: (2015)

Membrane anchoring facilitates colocalization of enzymes in plant cytochrome P450 redox systems
por: Laursen, Tomas, et al.
Publicado: (2021)

Fungal Cytochrome P450s and the P450 Complement (CYPome) of Fusarium graminearum
por: Shin, Jiyoung, et al.
Publicado: (2018)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
por: Wang, Hao, et al.
Publicado: (2020)

The planetary biology of cytochrome P450 aromatases
por: Gaucher, Eric A, et al.
Publicado: (2004)

The cytochromes P450 and mechanisms of chemical carcinogenesis.
por: Parke, D V
Publicado: (1994)

Cytochromes P450: a success story
por: Werck-Reichhart, Danièle, et al.
Publicado: (2000)

Basic Review of the Cytochrome P450 System
por: McDonnell, Anne M, et al.
Publicado: (2013)

The cytochrome P450 (CYP) superfamily in cnidarians
por: Pankov, Kirill V., et al.
Publicado: (2021)

Data for molecular dynamics simulations of B-type cytochrome c oxidase with the Amber force field
por: Yang, Longhua, et al.
Publicado: (2016)

Data for molecular dynamics simulations of Escherichia coli cytochrome bd oxidase with the Amber force field
por: Ahn, Surl-Hee, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_gr83tbi78mkmn5hj5i59j7gm94