Cargando…

Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population

In the general population, there is a strong inverse relationship between the number of ideal cardiovascular health (CVH) metrics and the total incidence of cardiovascular diseases and stroke. However, the prevalence of ideal CVH is extremely low and there are few studies on its association with new...

Descripción completa

Detalles Bibliográficos
Autores principales: Fan, Changfeng, Zhang, Qian, Zhang, Shufeng, Wang, Anxin, Bi, Xinwei, Chen, Shengyun, Li, Zhaoxia, Wu, Shouling, Zhao, Xingquan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190703/
https://www.ncbi.nlm.nih.gov/pubmed/32350306
http://dx.doi.org/10.1038/s41598-020-63927-3
_version_ 1783527738319044608
author Fan, Changfeng
Zhang, Qian
Zhang, Shufeng
Wang, Anxin
Bi, Xinwei
Chen, Shengyun
Li, Zhaoxia
Wu, Shouling
Zhao, Xingquan
author_facet Fan, Changfeng
Zhang, Qian
Zhang, Shufeng
Wang, Anxin
Bi, Xinwei
Chen, Shengyun
Li, Zhaoxia
Wu, Shouling
Zhao, Xingquan
author_sort Fan, Changfeng
collection PubMed
description In the general population, there is a strong inverse relationship between the number of ideal cardiovascular health (CVH) metrics and the total incidence of cardiovascular diseases and stroke. However, the prevalence of ideal CVH is extremely low and there are few studies on its association with newly found asymptomatic intracranial arterial stenosis (AICAS). Therefore, we performed this prospective study to assess the relationship between the newly found AICAS and ideal CVH metrics in the Chinese community population. Seven ideal CVH metrics of 3,475 participants in the Asymptomatic Polyvascular Abnormalities Community study (APAC) conducted in China (1,962 men and 1,513 women between the ages of 45 and 75 years) were collected. Based on the occurrence of newly found AICAS, all participants were divided into the AICAS group and non-ICAS group. Prevalence of ideal CVH metrics was compared between the two groups. Logistic regression was used to estimate the association of newly found AICAS with ideal CVH metrics. The result was the number of ideal CVH metrics was strongly associated with age, gender, education levels and family income (each P < 0.0001). Among the seven CVH metrics total cholesterol (TC) was the only one showing significant difference between the newly found AICAS group and non-ICAS group in our 2 years observation. Participants with less ideal CVH metrics (≤3) were associated with significantly higher prevalence of AICAS than those with more (>3) ideal CVH metrics (OR, 1.27; P = 0.045). Furthermore, less (≤3) ideal CVH metrics was markedly associated with higher incidence of AICAS for all participants, younger participants (<60 years) (OR, 1.34; P = 0.046) and men participants (OR, 1.53; P = 0.032) after adjustment for gender, age, education level, family income and stroke history. Thus we conclude that participants with newly found AICAS have high prevalence of total cholesterol status, and Individuals with low ideal CVH metrics (≤3) are associated with significantly higher prevalence of asymptomatic ICAS, especially in high-risk population of young and men participants. Therefore, primordial prevention of stroke should also focus on those high-risk populations.
format Online
Article
Text
id pubmed-7190703
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Nature Publishing Group UK
record_format MEDLINE/PubMed
spelling pubmed-71907032020-05-05 Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population Fan, Changfeng Zhang, Qian Zhang, Shufeng Wang, Anxin Bi, Xinwei Chen, Shengyun Li, Zhaoxia Wu, Shouling Zhao, Xingquan Sci Rep Article In the general population, there is a strong inverse relationship between the number of ideal cardiovascular health (CVH) metrics and the total incidence of cardiovascular diseases and stroke. However, the prevalence of ideal CVH is extremely low and there are few studies on its association with newly found asymptomatic intracranial arterial stenosis (AICAS). Therefore, we performed this prospective study to assess the relationship between the newly found AICAS and ideal CVH metrics in the Chinese community population. Seven ideal CVH metrics of 3,475 participants in the Asymptomatic Polyvascular Abnormalities Community study (APAC) conducted in China (1,962 men and 1,513 women between the ages of 45 and 75 years) were collected. Based on the occurrence of newly found AICAS, all participants were divided into the AICAS group and non-ICAS group. Prevalence of ideal CVH metrics was compared between the two groups. Logistic regression was used to estimate the association of newly found AICAS with ideal CVH metrics. The result was the number of ideal CVH metrics was strongly associated with age, gender, education levels and family income (each P < 0.0001). Among the seven CVH metrics total cholesterol (TC) was the only one showing significant difference between the newly found AICAS group and non-ICAS group in our 2 years observation. Participants with less ideal CVH metrics (≤3) were associated with significantly higher prevalence of AICAS than those with more (>3) ideal CVH metrics (OR, 1.27; P = 0.045). Furthermore, less (≤3) ideal CVH metrics was markedly associated with higher incidence of AICAS for all participants, younger participants (<60 years) (OR, 1.34; P = 0.046) and men participants (OR, 1.53; P = 0.032) after adjustment for gender, age, education level, family income and stroke history. Thus we conclude that participants with newly found AICAS have high prevalence of total cholesterol status, and Individuals with low ideal CVH metrics (≤3) are associated with significantly higher prevalence of asymptomatic ICAS, especially in high-risk population of young and men participants. Therefore, primordial prevention of stroke should also focus on those high-risk populations. Nature Publishing Group UK 2020-04-29 /pmc/articles/PMC7190703/ /pubmed/32350306 http://dx.doi.org/10.1038/s41598-020-63927-3 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Article
Fan, Changfeng
Zhang, Qian
Zhang, Shufeng
Wang, Anxin
Bi, Xinwei
Chen, Shengyun
Li, Zhaoxia
Wu, Shouling
Zhao, Xingquan
Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population
title Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population
title_full Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population
title_fullStr Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population
title_full_unstemmed Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population
title_short Association of Newly Found Asymptomatic Intracranial Artery Stenosis and Ideal Cardiovascular Health Metrics in Chinese Community Population
title_sort association of newly found asymptomatic intracranial artery stenosis and ideal cardiovascular health metrics in chinese community population
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190703/
https://www.ncbi.nlm.nih.gov/pubmed/32350306
http://dx.doi.org/10.1038/s41598-020-63927-3
work_keys_str_mv AT fanchangfeng associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT zhangqian associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT zhangshufeng associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT wanganxin associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT bixinwei associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT chenshengyun associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT lizhaoxia associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT wushouling associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation
AT zhaoxingquan associationofnewlyfoundasymptomaticintracranialarterystenosisandidealcardiovascularhealthmetricsinchinesecommunitypopulation