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New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression

Tumor cells demonstrate substantial plasticity in their genotypic and phenotypic characteristics. Epithelial-mesenchymal plasticity (EMP) can be characterized into dynamic intermediate states and can be orchestrated by many factors, either intercellularly via epigenetic reprograming, or extracellula...

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Autores principales: Bhatia, Sugandha, Wang, Peiyu, Toh, Alan, Thompson, Erik W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190792/
https://www.ncbi.nlm.nih.gov/pubmed/32391381
http://dx.doi.org/10.3389/fmolb.2020.00071
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author Bhatia, Sugandha
Wang, Peiyu
Toh, Alan
Thompson, Erik W.
author_facet Bhatia, Sugandha
Wang, Peiyu
Toh, Alan
Thompson, Erik W.
author_sort Bhatia, Sugandha
collection PubMed
description Tumor cells demonstrate substantial plasticity in their genotypic and phenotypic characteristics. Epithelial-mesenchymal plasticity (EMP) can be characterized into dynamic intermediate states and can be orchestrated by many factors, either intercellularly via epigenetic reprograming, or extracellularly via growth factors, inflammation and/or hypoxia generated by the tumor stromal microenvironment. EMP has the capability to alter phenotype and produce heterogeneity, and thus by changing the whole cancer landscape can attenuate oncogenic signaling networks, invoke anti-apoptotic features, defend against chemotherapeutics and reprogram angiogenic and immune recognition functions. We discuss here the role of phenotypic plasticity in tumor initiation, progression and metastasis and provide an update of the modalities utilized for the molecular characterization of the EMT states and attributes of cellular behavior, including cellular metabolism, in the context of EMP. We also summarize recent findings in dynamic EMP studies that provide new insights into the phenotypic plasticity of EMP flux in cancer and propose therapeutic strategies to impede the metastatic outgrowth of phenotypically heterogeneous tumors.
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spelling pubmed-71907922020-05-08 New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression Bhatia, Sugandha Wang, Peiyu Toh, Alan Thompson, Erik W. Front Mol Biosci Molecular Biosciences Tumor cells demonstrate substantial plasticity in their genotypic and phenotypic characteristics. Epithelial-mesenchymal plasticity (EMP) can be characterized into dynamic intermediate states and can be orchestrated by many factors, either intercellularly via epigenetic reprograming, or extracellularly via growth factors, inflammation and/or hypoxia generated by the tumor stromal microenvironment. EMP has the capability to alter phenotype and produce heterogeneity, and thus by changing the whole cancer landscape can attenuate oncogenic signaling networks, invoke anti-apoptotic features, defend against chemotherapeutics and reprogram angiogenic and immune recognition functions. We discuss here the role of phenotypic plasticity in tumor initiation, progression and metastasis and provide an update of the modalities utilized for the molecular characterization of the EMT states and attributes of cellular behavior, including cellular metabolism, in the context of EMP. We also summarize recent findings in dynamic EMP studies that provide new insights into the phenotypic plasticity of EMP flux in cancer and propose therapeutic strategies to impede the metastatic outgrowth of phenotypically heterogeneous tumors. Frontiers Media S.A. 2020-04-23 /pmc/articles/PMC7190792/ /pubmed/32391381 http://dx.doi.org/10.3389/fmolb.2020.00071 Text en Copyright © 2020 Bhatia, Wang, Toh and Thompson. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Biosciences
Bhatia, Sugandha
Wang, Peiyu
Toh, Alan
Thompson, Erik W.
New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
title New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
title_full New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
title_fullStr New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
title_full_unstemmed New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
title_short New Insights Into the Role of Phenotypic Plasticity and EMT in Driving Cancer Progression
title_sort new insights into the role of phenotypic plasticity and emt in driving cancer progression
topic Molecular Biosciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190792/
https://www.ncbi.nlm.nih.gov/pubmed/32391381
http://dx.doi.org/10.3389/fmolb.2020.00071
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