Targeting codon 158 p53-mutant cancers via the induction of p53 acetylation

Gain of function (GOF) DNA binding domain (DBD) mutations of TP53 upregulate chromatin regulatory genes that promote genome-wide histone methylation and acetylation. Here, we therapeutically exploit the oncogenic GOF mechanisms of p53 codon 158 (Arg(158)) mutation, a DBD mutant found to be prevalent...

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Detalles Bibliográficos
Autores principales: Kong, Li Ren, Ong, Richard Weijie, Tan, Tuan Zea, Mohamed Salleh, Nur Afiqah Binte, Thangavelu, Matan, Chan, Jane Vin, Koh, Lie Yong Judice, Periyasamy, Giridharan, Lau, Jieying Amelia, Le, Thi Bich Uyen, Wang, Lingzhi, Lee, Miyoung, Kannan, Srinivasaraghavan, Verma, Chandra S., Lim, Chwee Ming, Chng, Wee Joo, Lane, David P., Venkitaraman, Ashok, Hung, Huynh The, Cheok, Chit Fang, Goh, Boon Cher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7190866/
https://www.ncbi.nlm.nih.gov/pubmed/32350249
http://dx.doi.org/10.1038/s41467-020-15608-y

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